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Vaginal gel for treating gynecologic diseases, and preparation method thereof

A technology of gel and vagina, which is applied in the field of medicine to achieve the effects of enhancing drug efficacy, increasing comfort and compliance

Inactive Publication Date: 2009-11-18
北京法玛赛科医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both have good anti-inflammatory and anti-viral effects, and the combination of the two extracts for gynecological diseases has not been reported in the literature

Method used

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  • Vaginal gel for treating gynecologic diseases, and preparation method thereof
  • Vaginal gel for treating gynecologic diseases, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prescription: Houttuynia cordata 4000g, honeysuckle 2000g

[0034] Take Houttuynia cordata medicinal material, add 8 times the amount of distilled water, after wetting, steam distillation to extract volatile oil for 5 hours, take the volatile oil for later use; take honeysuckle medicinal material, add 8 times the amount of hot water to moisten, leaching 3 times at 80 °C, filter After that, the filtrate was combined, concentrated under reduced pressure, so that the volume of the medicinal solution and the weight of the medicinal material were 1: 1 (ml: g), centrifuged at a high speed, added to the treated macroporous adsorbent resin, washed with water first, and then washed with 30% Rinse with ethanol, collect 30% ethanol eluate, recover ethanol under reduced pressure, concentrate under reduced pressure to dryness, and obtain the total organic acid extract of Lonicera japonica.

[0035] Dissolve Carbomer-934 into a 4% aqueous solution with distilled water, then mix evenl...

Embodiment 2

[0037] Prescription: Houttuynia cordata 4000g, honeysuckle 4000g

[0038] Take Houttuynia cordata medicinal material, add 10 times the amount of distilled water, after wetting, steam distillation to extract volatile oil for 4 hours, take the volatile oil for later use; take honeysuckle medicinal material, add 10 times the amount of hot water to moisten, leaching twice at 80 °C, filter After that, the filtrate was combined, concentrated under reduced pressure, so that the volume of the medicinal solution and the weight of the medicinal material were 1:1 (ml:g), centrifuged at a high speed, added to the processed AB-8 macroporous adsorption resin, and first used 2 times the column volume Rinse with 60% ethanol of 4 times the column volume, collect the 60% ethanol eluate, reclaim the ethanol under reduced pressure, and concentrate to dryness under reduced pressure to obtain the total organic acid extract of Flos Lonicerae.

[0039] Dissolve Carbomer-934 into a 4% aqueous solution...

Embodiment 3

[0041] Prescription: Houttuynia cordata 4000g, honeysuckle 2000g

[0042]Take Houttuynia cordata medicinal material, add 8 times the amount of distilled water, after wetting, steam distillation to extract volatile oil for 5 hours, take the volatile oil for later use; take honeysuckle medicinal material, add 10 times the amount of hot water to moisten, leaching twice at 80 °C, filter After that, the filtrate was combined, concentrated under reduced pressure, so that the volume of the medicinal solution and the weight of the medicinal material were 1:1 (ml:g), centrifuged at a high speed, added to the processed AB-8 macroporous adsorption resin, and first used 2 times the column volume Rinse with 40% ethanol of 4 times the column volume, collect the 40% ethanol eluate, reclaim the ethanol under reduced pressure, and concentrate to dryness under reduced pressure to obtain the total organic acid extract of Lonicerae japonica.

[0043] Dissolve Carbomer-934 into a 4% aqueous soluti...

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Abstract

The invention discloses a vaginal gel for treating gynecological inflammation, and a preparation method thereof. The vaginal gel is prepared mainly by taking houttuynia volatile oil and honeysuckle total organic acids as effective components. Meanwhile, the invention also discloses a method for preparing the vaginal gel. The method ensures higher content of the effective components by extracting, enriching and purifying houttuynia and honeysuckle. The vaginal gel has the characteristics of convenient drug administration, good absorption and high efficacy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition composed of houttuynia cordata extract and honeysuckle extract for treating gynecological diseases, especially a gel of the pharmaceutical composition and a preparation method thereof. Background technique [0002] Vaginitis and cervicitis are the most common gynecological diseases. Vaginitis is a general term for various vaginal mucosal diseases caused by different etiologies. In a normal physiological state, the anatomical biochemical characteristics of the vagina are sufficient to prevent the invasion of external microorganisms. If the acidic environment of the vagina is damaged, pathogenic bacteria will take the opportunity to enter, leading to vaginal inflammation. The survey of women's reproductive health status shows that 53.86% of adult women have ever suffered from vaginitis, and 9.48% of them have repeated episodes for more th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61P15/00A61P15/02
Inventor 刘会臣
Owner 北京法玛赛科医药科技有限公司
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