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Optical fibre micro-fluidic biological sensor and preparation method thereof

A biosensor and microfluidic technology, applied in biological testing, fluorescence/phosphorescence, material inspection, etc., can solve the problems of inconvenient dynamic measurement and low efficiency of optical fiber biosensors, achieve dynamic real-time detection, reduce usage, Avoid the effects of cumbersome procedures

Active Publication Date: 2012-12-05
SOUTH CHINA UNIV OF TECH
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  • Abstract
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Problems solved by technology

[0004] The purpose of the present invention is to provide a microfluidic optical fiber biosensor and its preparation method for the problems of low efficiency and inconvenient dynamic measurement of the existing optical fiber biosensor

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  • Optical fibre micro-fluidic biological sensor and preparation method thereof
  • Optical fibre micro-fluidic biological sensor and preparation method thereof

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Embodiment Construction

[0028] The specific implementation of the present invention will be further described below in conjunction with the accompanying drawings.

[0029] Please refer to figure 1 ,Depend on figure 1 It can be seen that the microfluidic optical fiber biosensor of the present invention includes a light source 1 and a transmission optical path (that is, a transmission optical fiber 2 ), a sample flow path 4→5→6, a signal light collection optical path 5 and a signal processing device 7 . The light source 1 uses an Ar ion laser with a wavelength of 488nm, and the power is 50mW; the optical fiber 2 uses a multimode quartz glass optical fiber with a core diameter of 62.5 μm and a cladding diameter of 125 μm; the transmission optical fiber 2 is drawn by a fiber taper machine with a diameter of Optical fiber filament 3 with a length of 10 μm and a length of 3 cm; the capillary 4 is a quartz tube with a diameter of 2 mm and an inner diameter of 1.2 mm; the drawn optical fiber filament is wou...

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Abstract

The invention provides an optical fibre micro-fluidic biological sensor and a preparation method thereof. The optical fibre micro-fluidic biological sensor comprises a light source, a transmission light path, a biological sample stream, a signal light acquisition light path and a signal processing device. The preparation method of the optical fibre micro-fluidic biological sensor comprises the following steps: pulling the middle local position of optical fiber to be filament with diameter being less than 10 micrometers and length being 1mm-10cm; tightly winding the pulled filament on the outer wall of a capillary with diameter being less than 2mm; leading optical coupling sent by the light source to enter one end of the optical fiber, and connecting the other end of the optical fiber witha data processing system. A biological sample with fluorescence labeling is led into the capillary, and the concentration of the biological sample is measured according to optical information of fluorescence intensity and the like. The invention can replace the prior evanescent wave test technology of preparing the optical fiber into an optical fiber probe, combines with the micro-fluidic technology and is convenient for the dynamic real-time detection of the trace biological sample.

Description

technical field [0001] The invention relates to an optical fiber biosensor, in particular to an optical fiber microfluidic biosensor and a preparation method thereof. Background technique [0002] Optical fiber biosensor has good insulation and shielding effect, strong anti-electromagnetic interference ability, remote control real-time dynamic measurement, and has attracted extensive attention. Among optical fiber biosensors, optical fiber evanescent wave biosensor is the most widely used one. The sensor is used When the light wave is transmitted in the optical fiber in a way of total reflection, an evanescent wave is generated in the medium where the optical fiber probe is located. substance, so as to realize the determination of the concentration of the substance to be measured. [0003] Traditional optical fiber evanescent wave biosensors mainly use optical fibers as probes, and a large number of separate components are used in the excitation optical path and signal dete...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48G01N21/64
Inventor 杨中民冯洲明徐善辉
Owner SOUTH CHINA UNIV OF TECH
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