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Preparation and new usage of selaginella tamariscina biflavone ingredient

A technology of biflavonoids and selaginella, which is applied in the field of medicine, and can solve problems such as undiscovered and undiscovered total flavonoids of selaginella, cardiovascular diseases, etc.

Inactive Publication Date: 2009-08-26
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Before the completion of the present invention, there was no report about the total flavonoids of Selaginella chinensis and its biflavones as anti-myocardial ischemia, nor did it find that the total flavonoids of Selaginella and its biflavonoids of Selaginella chinensis were used to treat cardiovascular diseases caused by myocardial ischemia, etc. clinical application of disease

Method used

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  • Preparation and new usage of selaginella tamariscina biflavone ingredient
  • Preparation and new usage of selaginella tamariscina biflavone ingredient
  • Preparation and new usage of selaginella tamariscina biflavone ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 , Extraction and preparation of the total flavonoids of Selaginella chinensis and the biflavonoids of Selaginella spica:

[0056] Medicinal material 1kg, reflux extraction with 8 times the amount of 55% ethanol for 2 times, each extraction for 2 hours, the extract was filtered, the filtrate was directly passed through the pre-treated polyamide column, the polyamide adsorption part was eluted with 80% ethanol, and the solvent was recovered. Dried to obtain the total flavonoids of Selaginella. The total flavonoid content of Selaginella is 87.8%. Dissolve and filter the total flavonoids of Selaginella with 55-60% ethanol, carry out secondary adsorption purification on the polyamide column, elute the part absorbed by the polyamide with 80% ethanol, collect the ethanol eluate, add 0.2% activated carbon for decolorization, Filtrate, recover the solvent, leave to precipitate, and obtain the biflavone monomer component of Suicha spiconiae. The content of biflavonoi...

Embodiment 2

[0057] Example 2 , Extraction and preparation of the total flavonoids of Selaginella chinensis and the biflavonoids of Selaginella spica:

[0058] Medicinal material 1kg, reflux extraction with 8 times the amount of 60% methanol for 3 times, each extraction for 2 hours, the extract was filtered, the filtrate was directly passed through the pre-treated polyamide column, the polyamide adsorption part was eluted with 80% methanol, and the solvent was recovered. Dried to obtain the total flavonoids of Selaginella. The total flavonoid content of Selaginella is 89.2%. The total flavonoids of Selaginella are dissolved with 55-60% methanol, filtered, and subjected to secondary adsorption purification on a polyamide column, and the polyamide adsorbed part is eluted with 80% methanol, and the methanol eluate is collected and decolorized by adding 0.2% activated carbon. Filtrate, recover the solvent, leave to precipitate, and obtain the biflavone monomer component of Suicha spiconiae....

Embodiment 3

[0059] Example 3 , (capsules)

[0060] 100g of abiflavonoids or total flavonoids raw materials, appropriate amount of medicinal starch, mixed evenly, granulated, dried, granulated, filled into No. 1 capsules, made into 1000 capsules, and ready. 1 capsule each time, 3 times a day.

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PUM

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Abstract

In the invention, methods such as ethyl alcohol extraction and polyamide column chromatography and the like are employed to prepare high content selaginella general flavone and high purity amentotaxus biflavone monomer ingredients in large quantity from S. pvlvinata (Hook. et Gev.) Maxim, S. tamariscina (beav.) spring and S. moellendorfii Hieron of Selaginella for the first time. The selaginella general flavone and the amentotaxus biflavone monomer ingredients are proven to have the function of myocardial ischemia resistance and the new usage of curing angiocardiopathy caused by myocardial ischemia and the like.

Description

technical field [0001] The invention relates to the preparation and new application of the biflavone components of Selaginella chinensis, that is, the total flavonoids of Selaginella chinensis and the biflavone monomer components of Selaginella spica are obtained through solvent extraction and polyamide column chromatography separation and purification. To be precise, the total flavonoids of Selaginella and the biflavonoids of Selaginella spica extracted from Selaginella have the effect of anti-myocardial ischemia, and can be used to treat cardiovascular diseases caused by myocardial ischemia. Preparations of the drug are also involved. It belongs to the field of medical technology. Background technique [0002] Dried whole of Selaginella Selaginella (Selaginella) Selaginella Selaginella (Hook. et Gev.) Maxim, S. tamariscina (beav.) spring and Selaginella Hieron Grass. Selaginella plants have anti-cancer, anti-inflammation, anti-virus, analgesic, hypotensive, hypoglycemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K31/352A61P9/10
Inventor 赵全成王莲萍张莲珠南敏伦马吉胜赫玉芳
Owner 赵全成
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