Immune cell modification method and cell modification device

A modification method, cell technology, applied in the field of cell modification and cell modification equipment

Inactive Publication Date: 2009-08-19
KIST EURO FORSCHUNGSMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The agent or active substance is then released for reinforcement

Method used

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  • Immune cell modification method and cell modification device

Examples

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Embodiment Construction

[0047] Hereinafter, examples of the cell modification apparatus of the present invention are given, in which the modified immune cells of the present invention can be produced, or in which the cell modification method of the present invention can be performed.

[0048] exist figure 1In , a blood reservoir 1 (for example, a human blood stream) is shown schematically, from which blood is supplied to a cell separation device 4 through a filter device 3a. In the cell separation device 4 the desired cells, ie the cells to be modified, are selected in a known manner. Reference numeral 3 shows a filter fluid reservoir 3 from which filter fluid can be fed to the filter device 3 a via the valve 2 . The number of separated cells separated in the separation device 4 is determined in a known manner (for example in devices for impedance measurement) by means of the counting device 5 . In the first loading device 6a, the separated cells are incubated and loaded with the desired substance / ...

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Abstract

The present invention relates to a cell modification method for modifying human or mammal immune cells, especially effector cells outside the human or mammal body, wherein in a first step at least one encapsulated substance, preferably an active pharmaceutical ingredient, is introduced in and / or arranged on isolated human or mammal immune cells and wherein in a second step prior to or after the introduction of said at least one substance the cytotoxic effector function of the isolated immune cells is enhanced. The present invention also relates to a correspondingly modified human or mammal immune cell and to a cell modification device.

Description

technical field [0001] The present invention relates to cell modification methods and cell modification devices, which modify human or animal blood cell components, especially cells of the body's natural immune defense mechanism (such as T cells, NK cells, monocytes, macrophages or microglia) cells) so that said cells exert a therapeutic effect after introduction into a human or animal body, especially a mammalian body, for example against cancer (such as cancer of the lung or pancreas or ovary, breast or brain) or against other diseases, or to exert a diagnostic effect . The invention also relates to correspondingly modified immune cells. Background technique [0002] The use of active ingredients in medical treatments has been known for a long time. In these methods, the active ingredient is often delivered throughout the body of the human or animal. For example, the active ingredient may be administered orally or by injection; the active ingredient then distributes its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/06C12N5/08C12N5/10C12N15/09C12M1/00A61K35/14A61K35/12A61K47/46A61K49/00A61P25/28A61P29/00A61P35/00A61K35/17
Inventor 乌特·施泰因费尔德李爀熙
Owner KIST EURO FORSCHUNGSMBH
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