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Use of flumazenil in the manufacture of a medicament for the treatment of depressive disorders

A flumazenil and depression technology, applied in the application field of flumazenil in the production of drugs for the treatment of depression, can solve problems such as dependence and addiction

Inactive Publication Date: 2009-07-22
胡安·何塞·勒伽达·伊班内兹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the above-mentioned changes, some drugs for the treatment of depression may also cause symptoms of dependence and addiction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] sequentially administer low doses of flumazenil to patients

[0052] 1.1 Experimental program

[0053] Three patients with depression received this treatment. Patients P01 and P02 were reported to have taken cocaine and patient P03 had consumed alcohol. Data related to the SCL-90-R scale (Symptom Checklist 90 Revision, developed by Derogatis) are presented in Table 1:

[0054] Table 1

[0055] Data related to the SCL-90-R scale

[0056] patient code

age

gender

at the beginning

SCL-90-R at the end of

SCL-90-R P01 31 female 78 0 P02 35 male 48 30 P03 39 male 92 25

[0057] Appropriate information had previously been provided to the treated patients and appropriate informed consent had been obtained from them.

[0058] In the pre-experimental assessment, they first underwent a thorough psychological and medical evaluation in the morning (9 am). The medical examination includes an electrocardiogram and a...

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PUM

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Abstract

The invention relates to the use of flumazenil for the production of a medicament for the treatment of depressive disorders, for example disorders including depressive symptoms, without psychotic alteration. The flumazenil can be administered sequentially in small quantities at short intervals until a quantity that is therapeutically effective for the treatment of the depressive disorder has been administered.

Description

Technical field: [0001] The present invention relates to the use of a medicinal composition containing flumazenil (FLUMAZENIL) in the treatment of depression, especially in the treatment of depressive symptoms without psychotic changes. Background technique: [0002] Depression is a psychiatric disorder, including psychopathological disorders, characterized by changes in mood or affect leading to depression. This change is usually accompanied by a change in the overall level of activity. Most other symptoms are secondary to these changes, or a combination of them. These disorders are generally prone to relapse (ie, recurrent depressive episodes), and each depressive episode is often associated with a stressful situation or event. [0003] During an episode of depression, the person feels down, loses interest and enjoyment in things, and loses energy, which leads to reduced mobility and fatigue with every exertion. The following are also signs of a depressive episode: decr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5517A61P25/24
CPCA61K31/5517A61P25/24
Inventor 胡安·何塞·勒伽达·伊班内兹
Owner 胡安·何塞·勒伽达·伊班内兹
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