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Wild chrysanthemum effective component composition, preparation method and use thereof as well as medicinal preparation containing the same

A technology of effective parts and wild chrysanthemum is applied in the field of effective parts composition of wild chrysanthemum, preparation and application thereof, and pharmaceutical preparations containing the same, and can solve the problems of easy residual harmful substances, low product purity, large environmental pollution, etc. Short-term antihypertensive effect, good product purity, no organic solvent residue effect

Inactive Publication Date: 2009-07-01
上海雷允上科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These extraction methods are usually complicated, time-consuming, the product purity is not high, the environmental pollution is large, and harmful substances are easy to remain

Method used

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  • Wild chrysanthemum effective component composition, preparation method and use thereof as well as medicinal preparation containing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of the composition of the effective fraction of the wild chrysanthemum

[0035] A total of 100kg of wild chrysanthemums are extracted according to the following method:

[0036] Take 1 kg of wild chrysanthemum and put it into the extraction kettle of a supercritical extraction device, using supercritical carbon dioxide as the extraction solvent, extraction conditions: extraction pressure is 8MPa, extraction temperature is 45°C, analysis pressure is 5MPa, analysis temperature is 45°C, The extraction time was 2 hours, the flow rate of carbon dioxide was 190kg / hour, and the extract was collected to obtain the effective fraction 1 of Chrysanthemum chinensis.

[0037] Take the remaining 99kg of wild chrysanthemum, mix it with the supercritically extracted medicinal residues, add water to decoct twice for 1.5 hours each time, combine the decoctions, concentrate to 1.5g crude drug / ml medicinal liquid, add the equivalent volume of medicinal liquid 1 times...

Embodiment 2

[0044] Example 2 Preparation of the composition of the effective fraction of the wild chrysanthemum

[0045] A total of 100kg of wild chrysanthemums are extracted according to the following method:

[0046] Take 10kg of wild chrysanthemum and put it into the extraction kettle of the supercritical extraction device, use supercritical carbon dioxide as the extraction solvent, extraction conditions: extraction pressure is 10MPa, extraction temperature is 45°C, analysis pressure is 9MPa, analysis temperature is 50°C, The extraction time is 2 hours, the carbon dioxide flow rate is 200kg / hour, and the extract is collected to obtain the effective part 1 of Chrysanthemum chinensis.

[0047] Take another 90kg wild chrysanthemum flower, mix it with the medicinal residue after supercritical extraction, add water to decoct 2 times, each time for 1 hour, combine the decoction, concentrate to 1g crude drug / ml medicinal liquid, add the equivalent volume of medicinal liquid 1 Double the amou...

Embodiment 3

[0050] Example 3 Preparation of the composition of the effective fraction of the wild chrysanthemum

[0051] A total of 100kg of wild chrysanthemums are extracted according to the following method:

[0052] Take 10kg of wild chrysanthemum and put it into the extraction kettle of a supercritical extraction device, use supercritical carbon dioxide as the extraction solvent, extraction conditions: extraction pressure is 8MPa, extraction temperature is 50°C, analysis pressure is 5MPa, analysis temperature is 55°C, The extraction time was 2.5 hours, the flow rate of carbon dioxide was 160kg / hour, and the extract was collected to obtain the effective fraction 1 of Chrysanthemum chinensis.

[0053] Take another 90kg wild chrysanthemum flower, mix it with the medicinal residue after supercritical extraction, add water to decoct 2 times, each time for 1 hour, combine the decoction, concentrate to 1g crude drug / ml medicinal liquid, add the equivalent volume of medicinal liquid 1 Double...

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Abstract

The invention discloses a preparation method of combination of wild chrysanthemum effective parts and combination of wild chrysanthemum effective parts obtained by the said method. The preparation method comprises: taking 100 portions of wild chrysanthemum and performing supercritical fluid extraction of 1-100 portions of wild chrysanthemum and collecting the extract to obtain effective part 1; mixing the remained wild chrysanthemum, or dregs mixture after supercritical fluid extraction with water to decoct and then concentrating the decoction liquid and adding 90-95% ethanol(volumetric ratio) into the concentrated decoction liquid, standing and depositing, leaching the supernatant, concentrating the supernatant to be clear paste, adding adjuvant into the clear paste, drying, or directly drying the clear paste, thereby obtaining effective part 2; mixing the effective part 1 with the effective part 2. The invention also discloses a pharmaceutical preparation obtained by the combination of the wild chrysanthemum effective parts and use thereof in preparing antihypertensive drug. The combination of the wild chrysanthemum effective parts has overall drug-efficacy parts and gradual and long antihypertensive effect and good blood-pressure stabilization effect. The preparation method has features of quick speed, high extraction ratio, high product purity, simple flow, low energy consumption and no residual organic solvent.

Description

technical field [0001] The invention relates to a composition of active parts of wild chrysanthemum, its preparation method and application, and a pharmaceutical preparation containing it. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and it is also one of the largest epidemics. It often causes complications in the heart, brain, kidney and other organs, and seriously endangers human health. Early prevention and timely treatment are extremely important. The prevalence rate of hypertension among adults in my country is 18.8%, and the prevalence rate of hypertension among adults in big cities is 20.4%. , treatment rate and control rate were only 30.2%, 24.7% and 6.1%. These figures show that my country has become one of the countries most seriously affected by hypertension in the world. [0003] In addition, hypertension is one of the most important risk factors for stroke. Some stroke patients have high blood pressure or a...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P9/12
Inventor 樊敏伟谢德隆王冰宋崎李胜华马能溢张国明周国伟
Owner 上海雷允上科技发展有限公司
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