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Refining method of glycocyamine

A technology of guanidinoacetic acid and purification method, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as bad taste

Inactive Publication Date: 2009-06-24
上海浩洲化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purity of unrefined crude guanidinoacetic acid is about 98%, and the taste is not good, with a bitter taste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Add 50 mL of purified water and 50 g of guanidinoacetic acid to a 500 mL dry four-neck flask equipped with a reflux condenser, dropping funnel and thermometer, stir and heat to prepare a turbid solution of guanidinoacetic acid. Another 5 grams of sodium thiosulfate was dissolved in an appropriate amount of water to prepare an aqueous solution of sodium thiosulfate. An aqueous solution of 5 grams of sodium thiosulfate is added dropwise to the turbid solution of guanidinoacetic acid, heated while stirring while dropping, and the reaction temperature is controlled within 100°C. Then cool to below 30°C, filter with suction, rinse with a small amount of water, collect the solid and dry it to obtain the refined guanidinoacetic acid. Purity≥99%.

Embodiment 2

[0017] Add 250mL of purified water and 50 grams of guanidinoacetic acid into a 500mL dry four-necked flask equipped with a reflux condenser, dropping funnel and thermometer, stir and heat to prepare a turbid solution of guanidinoacetic acid. Another 25 grams of sodium thiosulfate was dissolved in an appropriate amount of water to prepare an aqueous solution of sodium thiosulfate. The aqueous solution of 25 grams of sodium thiosulfate is added dropwise to the turbid solution of guanidinoacetic acid, heated while stirring while dropping, and the reaction temperature is controlled within 100°C. Then cool to below 30°C, filter with suction, rinse with a small amount of water, collect the solid and dry it to obtain the refined guanidinoacetic acid. Purity≥99%.

Embodiment 3

[0019] Add 150mL of purified water and 50 grams of guanidinoacetic acid into a 500mL dry four-necked flask equipped with a reflux condenser, dropping funnel and thermometer, stir and heat to prepare a turbid solution of guanidinoacetic acid. Another 10 grams of sodium thiosulfate was dissolved in an appropriate amount of water to prepare an aqueous solution of sodium thiosulfate. The aqueous solution of 10 grams of sodium thiosulfate is added dropwise to the turbid solution of guanidinoacetic acid, heated while stirring while dropping, and the reaction temperature is controlled within 100°C. Then cool to below 30°C, filter with suction, rinse with a small amount of water, collect the solid and dry it to obtain the refined guanidinoacetic acid. Purity≥99%.

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PUM

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Abstract

The invention relates to a method for refining glycocyamine. The method comprises the steps as follows: A. certain quantity of crude glycocyamine is dispersed in water to prepare turbid glycocyamine solution; B. certain quantity of sodium hyposulfite is dissolved in the water to prepare sodium hyposulfite aqueous solution; C. the sodium hyposulfite aqueous solution obtained in step B is dropwise added into the turbid glycocyamine solution obtained in step A and simultaneously the turbid glycocyamine solution is stirred and heated to react for a period of time; D. mixed solution obtained in step C is cooled and filtered to collect solid substance; and E. the solid substance obtained in step D is dried to obtain a refined glycocyamine product. The method for refining the glycocyamine can prepare the refined glycocyamine product with the purity more than 99 percent.

Description

technical field [0001] The invention relates to a method for purifying chemicals, in particular to a method for refining guanidinoacetic acid. Background technique [0002] Guanidinoacetic acid is a white crystalline powder, mainly used as an intermediate in pharmaceutical synthesis, and can also be used as a food additive. The purity of unrefined crude guanidinoacetic acid is about 98%, and the taste is bad, containing a bitter taste. Contents of the invention [0003] Purpose of the present invention is exactly in order to provide a kind of refining method of guanidinoacetic acid. [0004] The object of the present invention is achieved in that a kind of refining method of guanidinoacetic acid comprises the following steps: [0005] A, get a certain amount of guanidinoacetic acid crude product and disperse in water, be mixed with guanidinoacetic acid turbid solution; [0006] B, get a certain amount of sodium thiosulfate and be dissolved in water, be mixed with sodium...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C279/14C07C277/08
Inventor 张伟庭
Owner 上海浩洲化工有限公司
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