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Chinese medicinal composition for treating phonosensitive nerve deafness and use thereof

A composition and neurological technology, which can be used in drug combinations, nervous system diseases, and medical preparations containing active ingredients, etc. The effect of ABR threshold shift and antagonism of GM ototoxicity

Inactive Publication Date: 2009-05-27
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved by the present invention is to obtain a simple and effective Chinese medicine composition in view of the shortcomings of Western medicines that have no specific medicine for deafness and the side effects of auxiliary medicines, and a large number of Chinese medicines for deafness.

Method used

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  • Chinese medicinal composition for treating phonosensitive nerve deafness and use thereof
  • Chinese medicinal composition for treating phonosensitive nerve deafness and use thereof
  • Chinese medicinal composition for treating phonosensitive nerve deafness and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 24g of Rehmannia glutinosa and 9g of Alisma, add 10 times the amount of double-distilled water to soak for 2 hours, boil with strong fire, decoct with slow fire for 0.5h, and take the liquid medicine. Add 8 times the amount of double-distilled water again, soak for 1 hour, boil with strong fire, decoct with slow fire for 0.5 hour, and take the medicinal solution. The two medicinal solutions were combined and concentrated in a water bath at 90°C. Add absolute ethanol at a volume ratio of 2:3, mix well, let stand at 4°C for 24 hours, centrifuge at 1500 rpm for 15 minutes, take the supernatant and discard the precipitate. Ethanol was evaporated in a water bath at 90°C, and the volume was adjusted to 270ml with three distilled water. Sterilize with a 0.22 μm small filter to prepare the kidney tonifying medicine. Store at 4°C, use within 5 days, and directly add to the culture system.

Embodiment 2

[0024] Weigh 22g of Rehmannia glutinosa and 8g of Alisma, add 10 times the amount of water to soak for 2 hours, boil with strong fire, decoct with slow fire for 0.5h, and take the liquid medicine. Add 8 times the amount of water again, soak for 1 hour, boil with strong fire, decoct with slow fire for 0.5 hour, and take the medicinal solution. The two medicinal liquids were combined, concentrated in a water bath at 90°C, and distilled to a volume of 135 ml to prepare the kidney tonifying medicine. Store at 4°C, use within 10 days, and take orally.

Embodiment 3

[0026] Weigh 22 g of rehmannia glutinosa and 18 g of Alisma chinensis, and the rest of the steps are the same as in Example 2 to prepare the kidney tonifying medicine.

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Abstract

The invention relates to a traditional Chinese medicine composition for treating sensorineural deafness, which is prepared by the following raw materials according to the parts by weight: 22-48 parts of prepared rhizome of rehmannia, and 8-18 parts of alisma orientale. The invention also relates to the application of the traditional Chinese medicine composition in preparing a medicine for treating sensorineural deafness. The traditional Chinese medicine composition has the efficacy of nourishing yin and supplementing kidney, promoting urination and expelling the heat-evil, can resist cochlear hair cell damage caused by gentamicin, improves listen function, has definite control efficiency for sensorineural deafness, and has the advantages of reliable healing efficacy, good stability and simple formulation, etc.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating sensorineural deafness; the invention also relates to the application of the traditional Chinese medicine composition. Background technique [0002] Deafness is a common multiple disease and one of the most important problems affecting the quality of human life. Clinical investigations in recent years have shown that people with obvious hearing impairment account for about 7%-10% of the world's total population. The incidence of deafness in my country is very high. According to relevant statistics, the number of people with hearing and language impairments in my country is as high as 20.57 million, of which about 2 million are children, about 800,000 are children under the age of 7, and 9.49 million are presbycusis. The overall incidence rate of hearing impairment in newborns is 9.52‰. In addition, the number of hearing-impaired persons is increasing at a rate of 20,000 t...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P25/02A61P27/16
Inventor 施建蓉董杨郭瑞新王静王毅敏宋海燕
Owner SHANGHAI UNIV OF T C M
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