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Ovulation cycle monitoring and management

A technology for monitoring systems and test strips, which can be used in measuring devices, biological testing, material inspection products, etc., and can solve problems such as misreading test results

Inactive Publication Date: 2009-03-18
MANAWATU BIOTECH INVESTMENTS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, a woman using a home assay with the aid of simple visual inspection may misinterpret the test results, especially when the test indications are inconsistent with the woman's expectations of her ovarian activity (although others may interpret the test differently)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0214] Preparation of polyclonal anti-PdG213-5 antibody-gold conjugate

[0215] Polyclonal anti-PdG Ab 213-5 was partially purified by octanoic acid precipitation followed by ammonium sulfate cleavage. The antibody was diluted 1 / 10 with 10 mM phosphate buffer (pH 7.4). Gold samples were 40nm microspheres (microsperes) from British Biocell International and were treated with 0.02M K 2 CO 3 Adjust to pH 7.8. Gold solution (10 mL) was added to 100 μL of 1 / 10 diluted Ab + 400 μL of 10 mM phosphate buffer (pH 7.4) then mixed by swirling and left at room temperature for 5-10 minutes. Blocking buffer (300 μL of 10% BSA in 10 mM phosphate buffer (pH 7.4)) was added and the solution was mixed by swirling vigorously, then left for 10 minutes. The mixture was then centrifuged at 6,000 rpm for 1 hour, the supernatant was discarded and the pellet was washed 3 times with 1 mL of storage buffer (2% BSA in PBS with azide). Resuspend the conjugate in 1 mL of storage buffer. Conjugation o...

Embodiment 2

[0217] Methods for human pregnancy avoidance and pregnancy realization

[0218] pregnancy avoidance

[0219] Growing follicles signal their presence through increasing rates of ElG excretion. Blackwell, L.F. and Brown J.B.. Steroids, 57, 554 (1992), incorporated herein by reference. Ovulation is indicated by a peak in the ElG excretion rate and a rising PdG excretion rate. Blackwell, L.F. et al., Steroids, 63, 5. (1998), which is incorporated herein by reference. The corpus luteum is indicated by a rapidly rising rate of PdG excretion. The normal cycle consists of three sequential phases: (1) the ovaries are silent (or inactive) infertile periods of varying length (I), which are manifested by persistently low rates of ElG and PdG excretion; Different lengths of the fertile phase (F) while growing in its life support system (follicles), which is indicated by the first statistically significant rise in the rate of ElG excretion while the rate of PdG excretion remains low; an...

Embodiment 3

[0228] Algorithm for identifying the first ElG rise

[0229]A method has been developed for identifying the first rise in ElG during the normal cycle, which is an adaptation of the Trigg tracking signal algorithm described in Blackwell L.F. and Brown J.B., Steroids Nov; 57(11):554-62 (1992). The tracking signal algorithm has been modified to give the expected detection of an ElG rise. The method is carried out by first determining four starting parameters. The starting parameters for this algorithm include: i) an initial value of the exponentially smoothed mean (ESA(0)), ii) an initial value of the mean mean deviation (MAD(0)), iii) an initial value of the forecast error (FE (0)) and iv) the initial value of the smoothed prediction error (SFE(0)). FE(0) and SFE(0) can be set to zero. Typically, ESA(0) and MAD(0) are calculated based on the first 6 baseline days of the period, if a baseline period exists. In this case, the tracking signal can only give an advance notice aft...

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Abstract

The invention relates to methods of monitoring the ovulation cycle of an animal by detecting specific analytes in body fluids, computer program products, devices, data processing systems, and kits for monitoring the ovulation cycle and determining the fertility of female mammals.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to provisional application U.S.S.N. 60 / 729,554, filed October 24, 2005, by Robert Gilmour and Len Blackwell, entitled "Ovulatory Cycle Monitoring and Management," the entire contents of which are incorporated herein by reference. technical field [0003] The field of the invention includes methods, devices, kits, and systems for monitoring, eg, the ovulation cycle of mammals. Background technique [0004] The following includes information useful in understanding the present invention. It is not an admission that any information presented herein is prior art on or pertaining to the presently described or claimed invention, or that any publication or document specifically or implicitly referenced is prior art. [0005] The potentially fertile period of the ovulatory menstrual cycle, sometimes called the window offertility, is the period during which a female animal can become pregnant f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/558
CPCG01N33/558G01N33/689G01N33/54388G01N33/48G01N33/53
Inventor 罗伯特·吉尔摩莱昂纳德·弗朗西斯·布莱克韦尔
Owner MANAWATU BIOTECH INVESTMENTS LTD
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