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Dry powder inhaler device

An inhaler and equipment technology, applied in the field of improvement of dry powder inhaler equipment, can solve the problems of difficulty in achieving the force, inability to inhale, resistance and the like

Inactive Publication Date: 2009-03-11
JAGOTEC AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009]While breath-actuated devices have undoubted advantages in that they avoid synchronization problems and help make dosing more reliable, in these devices the powder The efficiency of conveying and separating agglomerates depends only on the force of the patient's inhalation
Achieving this force can be quite difficult in extremely debilitated patients
Additionally, breakaway agglomerate devices such as those described above create some resistance to airflow, requiring greater inspiratory effort by the patient in order to inhale the full metered dose
Thus, there is a risk that highly debilitated patients, such as those experiencing an asthma attack or those suffering from COPD or CF, will not be able to inhale all or nearly all of the dose metered by the device

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0089] In this example, the fine particle fraction (average aerodynamic diameter of 4.4 microns or less) as a percentage of the dose delivered from a dry powder inhaler according to the invention is compared with a device with a mouthpiece, which The tubing has a single passage including the agglomerate separation device described in US Patent 6,182,655.

[0090] Measurements were performed by Dose Unit Sampling Apparatus (DUSA). This device is well known in the art and is described in USP Chapter 24 .

[0091] The device was operated at different airflow rates, producing in each case a pressure drop of 4 kPa over the specific dry powder inhaler tested.

[0092] The comparative device according to U.S. Patent 6,182,655 with a single access through the mouthpiece gave a delivered dose of 8.8 mg, and a fine particle fraction of 36.8% (RSD of FPF of the delivered dose = 0.5%; n = 3) points (less than or equal to 3.3 microns).

[0093] The four devices were identical to the com...

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PUM

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Abstract

A DPI device comprising a dispensing chamber for receiving a discrete dose of medicament-containing powder and means for delivering said dose from the dispensing chamber to a patient in an air-flow that passes from the chamber to the patient via a mouth-piece along a first air passage that comprises de-agglomerating means, the device additionally comprises a second air passage in fluid communication with the dispensing chamber and the mouth-piece and which by-passes the de- agglomerating means and which is located such that it receives a portion of said air-flow that is free, or substantially free, of powder.

Description

technical field [0001] The present invention relates to improvements in dry powder inhaler devices, particularly breath activated dry powder inhaler devices, for delivering medicinal substances to the airways of a patient. Background technique [0002] Asthma and other respiratory conditions have been treated with inhaled medications for a long time. The drug can be presented as a solution or suspension in an aerosol propellant and delivered from a pressurized metered dose inhaler. Alternatively, they may be presented as a dry powder alone or mixed with a suitable carrier material, such as lactose. The present invention relates to devices for delivering dry powders, so-called Dry Powder Inhalers or DPIs for short. [0003] DPI can be used for the dispensing of either single pre-metered doses of a drug comprising a powder that is placed into a dispensing chamber prior to use, or sequential metered doses of a powder contained in a large reservoir that can be delivered to a d...

Claims

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Application Information

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IPC IPC(8): A61M15/00
CPCA61M2015/0026A61M2015/0025A61M15/0025A61M11/002A61M15/0065A61M15/0026A61M15/0091A61M2202/064A61M2011/002A61M15/0076A61M15/0081A61M15/0093A61M15/0096
Inventor R·米勒-沃尔兹T·埃吉曼
Owner JAGOTEC AG
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