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Natural zeolite emergence haemostatic and preparation method thereof

A technology of natural zeolite and hemostatic agent, which is applied in the direction of blood diseases, medical formulas, medical preparations containing active ingredients, etc., to achieve the effect of less heat release, rich raw materials, and heat reduction

Inactive Publication Date: 2009-02-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no domestic and foreign patent reports on the application of natural zeolite in blood coagulation materials, wound treatment and trauma repair, and the combination of natural zeolite with medical bandages and medical adhesives for trauma repair

Method used

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  • Natural zeolite emergence haemostatic and preparation method thereof
  • Natural zeolite emergence haemostatic and preparation method thereof
  • Natural zeolite emergence haemostatic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Choose Jinyun natural zeolite as raw material, the XRD pattern of Jinyun natural clinoptilolite is shown in the attached figure 1 , SEM image see image 3 ; The XRD pattern of Jinyun natural mordenite is shown in the attached figure 2 , the SEM image is attached Figure 4 .

[0040] A certain amount of Jinyun natural zeolite is put into a traditional Chinese medicine pulverizer, and the pulverization time is about 5 minutes; the particle size obtained after pulverization is 1 micron to 1 mm. The crushed natural zeolite was dried in an oven at 100° C. for 1 h. Its hemostatic effect is similar to that of Quikclot, see attached Figure 5 .

Embodiment 2

[0042] Take a certain amount of pulverized Jinyun natural mordenite and mix it with 20% sodium chloride solution at a solid-to-liquid ratio of 1g / 10ml, react at 100°C for 2h, and then filter with suction; this process is repeated three times to obtain Sodium natural zeolite. The sodium-rich natural mordenite obtained above was dried in an oven at 100° C. for 24 hours. Its hemostatic effect is good, see attached Figure 6 .

Embodiment 3

[0044] The modified sodium-type natural zeolite and CaCl with a concentration of 1.0mol / L 2 Mix according to the solid-to-liquid ratio of 1g / 20ml, react at room temperature for 24h, wash with deionized water until there is no Ca in the solution 2+ , and dried in an oven at 100° C. for 24 hours to obtain modified calcium-rich natural mordenite and natural clinoptilolite. See attached for its hemostatic effect Figure 6 .

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Abstract

The invention relates to an external natural zeolite emergency survival haemostatic which adopts a natural zeolite haemostatic or a modified natural zeolite haemostatic directly; the raw materials of the natural zeolite comprises the following components: silicon oxide, aluminum oxide, titanium oxide, ferric oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide; wherein, the total content of the silicon oxide and the aluminum oxide is more than 70 percent; the aperture of the natural zeolite is 0.3 to 0.2nm, the specific surface area is 30 to 1,000m<2> / g and the pore volume is 0.2 to 1.0cm<3> / g, and the diameter of particles of the natural zeolite haemostatic is 1mum to 1mm. The preparation method is simple and the hemostatic effect is good, thus being used for hemostasis in different medical situations.

Description

technical field [0001] The invention relates to a natural zeolite emergency life-saving hemostatic agent for external use and a preparation method thereof, in particular to a natural zeolite hemostatic agent for treating fatal large-vessel hemorrhage uncontrollable by conventional hemostatic measures and a preparation process thereof. Background technique [0002] Emergency life-saving hemostatic agent is an emerging research field in the world. Emergency life-saving hemostats are primarily developed for emergencies where bleeding does not stop in trauma. An emergency like aortic bleeding can be contained within a short period of time (3 minutes), gaining valuable time for further medical treatment. [0003] According to the statistics of the Ministry of Health in 2002, trauma and poisoning ranked fifth among the top ten causes of death, and the number of people who lost their lives every year was as high as 9.5 million. Excessive blood loss is the single largest contribut...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P7/06
Inventor 范杰李云龙肖丽萍杨靖郑小明
Owner ZHEJIANG UNIV
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