Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Clerodendrum bungei extract and use thereof for treating airway hyperreactivity

A technology of airway hyperresponsiveness and stinky peony, which is applied to respiratory diseases, drug combinations, plant raw materials, etc., and can solve problems that do not involve airway inflammation or airway hyperresponsiveness, and have few active ingredients

Inactive Publication Date: 2011-03-30
CENT SOUTH UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few studies on its active ingredients, and none of them involve airway inflammation or airway hyperresponsive diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity
  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity
  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Separation and preparation of triterpenoid extracts of smelt peony

[0017] Wash and dry the whole wild peony plant, weigh 100 grams, cut into pieces and add to a 2L round bottom flask, add 1L of 50% ethanol; place the round bottom flask in a water bath at 82°C and heat and reflux for 4 hours. Recover the reflux liquid. Then add 1L of 50% ethanol and repeat the above operation once. Then combine the extracts, pour them into a beaker, concentrate and evaporate to dryness; add 200ml of double-distilled water and stir to form a suspension; then extract twice with 200ml of petroleum ether, separate and discard the extract, and then extract twice with 200ml of chloroform. The chloroform extract is recovered. Take 0.1ml from the chloroform extract for pre-test inspection of its composition, and the rest is concentrated and evaporated to dryness. The concentrate is weighed, about 0.7g.

[0018] Then the concentrate is made into an emulsifier, and the method is as foll...

Embodiment 2

[0023] Example 2: The effect of triterpenoid extract of odorous tree peony on a mouse model of airway hyperresponsiveness

[0024] 1. Animal grouping and treatment: 50 Kunming mice were randomly divided into 5 groups. The way of administration is gavage, the gavage amount is 1ml / 100g body weight.

[0025] ① Normal control group: Gavage with normal saline once a day for 7 consecutive days;

[0026] ②Smelly tree peony triterpenoid control group: gavage the odor of tree peony triterpenoid emulsifier once a day for 7 consecutive days;

[0027] ③Airway hyperresponsiveness model group: Gavage with normal saline every night for 7 consecutive days, and attack with ozone every afternoon for 20 minutes from the third day of gavage for 5 consecutive days;

[0028] ④ Hormone treatment group (positive control): gavage 0.5 mg / ml glucocorticoid every night for 7 consecutive days, and attack with ozone every afternoon for 20 minutes on the third day of gavage for 5 consecutive days;

[0029] ⑤Smelly pe...

Embodiment 3

[0050] Example 3: Preparation of a medicinal preparation containing triterpenoid extract of odorous peony

[0051] Take the triterpenoid extract of Paeonia odorifera in Example 1, and prepare various pharmaceutically acceptable pharmaceutical compositions in various forms according to conventional methods known in the art:

[0052] Granules: Separately take the odorous peony triterpenoid extract, solidify the microcrystalline cellulose and starch and mix them evenly, use hypromellose as a binder to wet granulate, and dry the granules at 80 degrees Celsius to obtain odor Granules of peony triterpenoid extract.

[0053] Pellets: take the triterpenoid extract of odorous tree peony, respectively solidify by microcrystalline cellulose and starch, and mix them evenly with auxiliary materials. Use hypromellose as the binder and blank pill core as the substrate to prepare a diameter of 0.5 ~1.4 Pellets.

[0054] Capsules: Take the triterpenoid extracts of odorous tree peony, respectively sol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a clerodendron bungei extractive which is used for curing the airway hyperresponsiveness disease. A triterpenes extractive which is about 0.7 percent by weight percentage of the clerodendron bungei raw pesticide is obtained by a complete stool of the clerodendron bungei; the research shows that the triterpenes compound in the clerodendron bungei can relieve the pathologicalchanges in airway and alveolus, reduce the inflammation reaction and the airway hyperresponse, has the effect similar to the glucocorticoid, has the evident functions of reducing the airway hyperresponsiveness and relieving the airway and lung injury caused by the ozone stress, and can cure the effective part of the airway hyperresponsiveness disease; moreover, the experiment shows that the clerodendron bungei total extractive does not have the toxicity to the peripheral leukocytes, the liver and kidney and has good safety.

Description

Technical field [0001] The invention relates to a medicinal use of natural plant extracts, in particular to a peony extract and its use for treating airway hyperresponsive diseases. Background technique [0002] Airway hyperresponsiveness is a common clinical manifestation, mainly seen in acute and chronic respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, and viral upper respiratory tract infection. It is generally believed that the pathogenesis of airway hyperresponsiveness is airway inflammation, so drug treatment is mainly from two directions: anti-inflammatory and symptomatic treatment. At present, the commonly used drugs for the treatment of airway hyperresponsiveness are anti-inflammatory drugs and bronchodilators. There are two more certain types of anti-inflammatory drugs: corticosteroids and sodium cromolyn sodium nidolate. Among them, inhaled corticosteroids have been used. It has become the first-line medicine for the treatment of a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61P11/00
Inventor 秦晓群向阳邓政
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com