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Clerodendrum bungei extract and use thereof for treating airway hyperreactivity

A technology of stinky tree peony and its extract, applied in the field of stinky tree peony extract and its use for treating airway hyperresponsive diseases, which can solve the problems of not involving airway inflammation or airway hyperresponsive diseases, and few active ingredients

Inactive Publication Date: 2008-11-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few studies on its active ingredients, and none of them involve airway inflammation or airway hyperresponsive diseases

Method used

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  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity
  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity
  • Clerodendrum bungei extract and use thereof for treating airway hyperreactivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Separation and preparation of triterpenoid extract of stink peony

[0017] The whole plant of wild stinky peony, washed and dried, weighed 100 grams, cut it into pieces, put it into a 2L round bottom flask, added 1L of 50% ethanol; placed the round bottom flask in a water bath at 82°C, heated and refluxed for 4 hours, Recycle the reflux. Then add 1 L of 50% ethanol, and repeat the above operation once. Then combine the extracts, pour them into a beaker, concentrate and evaporate to dryness; add 200ml of double-distilled water, and stir to form a suspension; then extract twice with 200ml of petroleum ether, separate and discard the extracts, and then extract twice with 200ml of chloroform, The chloroform extract was recovered. Take 0.1ml from the chloroform extract to do a preliminary test of its composition, the rest is concentrated and evaporated to dryness, and the concentrate is weighed, which is about 0.7 grams.

[0018] Then the concentrate is made...

Embodiment 2

[0023] Example 2: The effect of the triterpenoid extract of stinky peony on the mouse airway hyperresponse model

[0024] 1. Animal grouping and treatment: 50 Kunming mice were randomly divided into 5 groups. The administration method is intragastric administration, and the intragastric administration volume is 1ml / 100g body weight.

[0025] ①Normal control group: gavage with normal saline once a day for 7 consecutive days;

[0026] ②The control group of triterpenoids of stinky peony triterpenoids: gavage once a day with the emulsifier of stinky peony triterpenoids extract for 7 consecutive days;

[0027] ③ Airway hyperresponse model group: gavage with normal saline every night for 7 consecutive days, and attack with ozone for 20 minutes every afternoon from the third day of gavage for 5 consecutive days;

[0028] ④ Hormone therapy group (positive control): gavage with 0.5 mg / ml glucocorticoid every night for 7 consecutive days, and attack with ozone for 20 minutes every aft...

Embodiment 3

[0050] Embodiment 3: the preparation of the pharmaceutical preparation containing the stink peony triterpenoid extract

[0051] Get the stink peony triterpene extract in Example 1, and prepare various pharmaceutically acceptable pharmaceutical compositions in various forms according to conventional methods known in the art:

[0052] Granules: take the triterpenoid extracts of stinky peony, mix them evenly after being solidified by microcrystalline cellulose and starch, wet granulate with hypromellose as a binder, and dry the granules at 80 degrees Celsius to obtain stinky Granules of tree peony triterpenoid extract.

[0053] Micropills: Take the triterpenoid extract of peony peony, solidify them with microcrystalline cellulose and starch, mix them evenly with auxiliary materials, use hypromellose as the binder, and use the blank pellet core as the substrate to prepare a pellet with a diameter of 0.5 ~1.4 pellets.

[0054] Capsules: take the triterpenoid extract of peony stin...

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PUM

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Abstract

The invention provides a clerodendron bungei extractive which is used for curing the airway hyperresponsiveness disease. A triterpenes extractive which is about 0.7 percent by weight percentage of the clerodendron bungei raw pesticide is obtained by a complete stool of the clerodendron bungei; the research shows that the triterpenes compound in the clerodendron bungei can relieve the pathological changes in airway and alveolus, reduce the inflammation reaction and the airway hyperresponse, has the effect similar to the glucocorticoid, has the evident functions of reducing the airway hyperresponsiveness and relieving the airway and lung injury caused by the ozone stress, and can cure the effective part of the airway hyperresponsiveness disease; moreover, the experiment shows that the clerodendron bungei total extractive does not have the toxicity to the peripheral leukocytes, the liver and kidney and has good safety.

Description

technical field [0001] The invention relates to a medical application of a natural plant extract, in particular to an extract of stink peony and its use for treating airway hyperresponsive diseases. Background technique [0002] Airway hyperresponsiveness is a common clinical manifestation, mainly seen in acute and chronic respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, and viral upper respiratory tract infection. It is generally believed that the pathogenesis of airway hyperresponsiveness is airway inflammation, so drug treatment is mainly from two directions of anti-inflammatory and symptomatic treatment. At present, there are two types of drugs commonly used in the treatment of airway hyperresponsiveness: anti-inflammatory drugs and bronchodilators. There are two types of anti-inflammatory drugs: corticosteroids and sodium cromoglycate and sodium nitrate. Among them, inhaled corticosteroids have been used. It has become the first-lin...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P11/00
Inventor 秦晓群向阳邓政
Owner CENT SOUTH UNIV
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