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Dectancyl mastication tablet for dogs and cats

A technology of dexamethasone acetate and chewable tablets, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of poor palatability, reduce waste and improve the cure rate Effect

Inactive Publication Date: 2008-07-16
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the physiological characteristics of dogs and cats, the inventor broke through the shortcomings of poor palatability of existing tablets, and developed a chewable tablet suitable for dogs and cats, which can be fully chewed and absorbed, effectively improving the utilization rate of therapeutic drugs , Guaranteed the dosage and improved the cure rate of dog and cat diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Dexamethasone acetate chewable tablet

[0019] Take 2400g of starch and bake at 100°C for 1 hour, cool to room temperature; take another 600g of dexamethasone acetate and 60g of aspartame, dilute and mix with the cooled starch in the same amount incremental dilution method, then pass through 60 meshes, and finely Mixture A was obtained by sieving three times. Put mixture A, 600 g of oral glucose, 600 g of skimmed milk powder and 1740 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. 2.5 L of absolute ethanol was taken, and 200 g of polyvinylpyrrolidone was added therein to make a polyvinylpyrrolidone-ethanol mixed solution.

[0020] Add the polyvinylpyrrolidone-ethanol mixed solution to the mixture B step by step under stirring until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with a 16-mesh sieve and ventilate and dry at 50°C. Accurately weigh 30g of m...

Embodiment 2

[0029] Embodiment 2: Dexamethasone acetate chewable tablet

[0030] Get starch 1410g, dexamethasone acetate 1200g, aspartame 210g and make mixture A by the method described in embodiment 1.

[0031] Put mixture A, 375g of oral glucose, 1125g of skimmed milk powder and 1950g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Take 2.5 L of absolute ethanol, and add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone-ethanol mixed solution as a binder.

[0032] Add the polyvinylpyrrolidone-ethanol mixed solution to the mixture B step by step under stirring until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. About 10,000 tablets were made, each weighing 0.6g, containing 0.12g of dexamethasone acetate.

Embodiment 3

[0033] Embodiment 3: Dexamethasone acetate chewable tablet

[0034] Get starch 2100g, dexamethasone acetate 1800g, aspartame 300g, prepare mixture A by the method described in embodiment 1. Put mixture A, 360 g of oral glucose, 1440 g of skim milk powder and 1500 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Take 2.5 L of absolute ethanol, and add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone-ethanol mixed solution as a binder.

[0035] Add the polyvinylpyrrolidone-ethanol mixed solution to the mixture B step by step under stirring until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were made, each weighing 0.6g, containing 0.18g of dexamethasone acetate.

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PUM

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Abstract

The invention discloses a dexamethasone acetate chewable tablet for canine and feline, which overcomes the shortcoming of poor palatability of the existing tablet, facilitates that the dexamethasone acetate chewable tablet is chewed and absorbed thoroughly by the cats and dogs to guarantee effective dosage, increases the cure rate of canine and feline diseases and reduces drug waste. The dexamethasone acetate chewable tablet of the invention comprises that (by weight percentage): 1-5 percent of aspartame, 20-30 percent of mixture of oral glucose and skim milk powder (the proportion of the oral glucose and the skim milk powder is 1:1-1:4); 40-60 percent of excipient, 0.5-1 percent of fluidizer and 10-30 percent of dexamethasone acetate respectively.

Description

technical field [0001] The invention relates to the preparation technology of veterinary medicine, in particular to a chewable tablet with good palatability for dogs and cats. Background technique [0002] Pet breeding has a long history in our country. With the improvement of living standards, the number of expensive dogs and cats is gradually increasing, and pet owners are paying more and more attention to the quality of life of their pets. Dogs and cats are mammals, and they also have their own common diseases. At present, the treatment of dog and cat diseases is mainly based on intravenous drip and intramuscular injection. Interruption of treatment often results in a poor prognosis of the disease. If dogs and cats can be made to actively take therapeutic drugs orally, this series of problems will be solved, but the few veterinary tablets currently on the market are often difficult to popularize because of their poor palatability. Contents of the invention [0003] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/20A61K47/46A61P29/00A61P37/08A61P17/00
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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