Method for preparing aminoglucose hydrochloride

Abstract

The invention provides a new method that prepares glucosamine hydrochloride by adopting chitosan, which comprises the steps of the hydrolysis of hydrochloric acid, the cooling crystallization of mother liquid, the concentration of filter liquid, the cooling crystallization of concentrated solution, decolorization, the crystallization of decolorized liquid, fining, etc. The preparation method of the invention adopts the cooling crystallization firstly after the hydrolysis and the concentration of filter liquid to cause the glucosamine hydrochloride to be separated from the liquid that contains relatively high impurity content and also cause grease and impurities to be separated and suspended at the top layer of crystalline solids, thus being beneficial for removing the grease and the impurities. The preparation method of the invention can obtain the glucosamine hydrochloride with high purity and high yield in the condition that hydrochloric acid concentration is 30-32 percent and reaction temperature is 85-88 DEG C and greatly reduces the dosage of activated carbon, thus greatly saving manufacturing cost.

Description

technical field [0001] The invention relates to a method for preparing glucosamine hydrochloride, in particular to a method for preparing D-glucosamine hydrochloride from chitin extracted from marine organisms such as shrimp and crab shells. Background technique [0002] Glucosamine hydrochloride (that is, D-glucosamine hydrochloride) is a drug for treating bone and joint diseases and an antibiotic synergist, as well as a sweetener and antioxidant for food, and can also be used as a nutritional supplement for diabetics. It can also inhibit the growth of cancer cells and is the main raw material for the synthesis of new anticancer drug chlorurecin. Glucosamine hydrochloride and its derivatives have broad application prospects in medicine, light industrial cosmetics and other fields. [0003] The method of preparing glucosamine hydrochloride from chitin generally adopts the hydrochloric acid hydrolysis method, that is, adding chitin to a certain concentration of hydrochloric ...

AI Technical Summary

Problems solved by technology

In order to obtain a relatively high product yield, it is generally achieved by increasing the concentration of hydrochloric acid or increasing the reaction temperature of hydrolysis. In the existing preparation process, the concentration of hydrochloric acid is 36-38%, but glucosamine hydrochloride is at a higher concentration. Under the condition of acid liquid and heat, it will cause complex compound and decomposition reactions, which not only deepens the color of the crude product, but also reduces the purity of the product and the yield of the product; when the concentration of hydrochloric acid decreases, the reaction temperature must be increased, generally to above 95°C-100°C, but blindly increasing the reaction temperature will also cause decomposition reactions, and it is easy to cause sticking phenomenon, which will affect the purity and yield of the product

In addition, the existing preparation process all adopts the method of hydrolyzing and filtering while hot. However, due to the high solubility of oil and impurities at high temperature, the impurities are easily filtered out together with the mother liquor, which not only affects the purity of the product, but also makes the subsequent The decolorization process needs to consume a large amount of activated carbon, which increases the cost of preparation

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