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Medicinal composition for regrouping human P43 protein and its application in medication

A technology of composition and human albumin, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of no specific drug for effective treatment of gastric adenocarcinoma and unclear tumor inhibitory spectrum

Inactive Publication Date: 2008-06-04
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, which kinds of solid tumors this protein has a higher tumor inhibitory rate, that is, the tumor inhibitory spectrum of this protein is still unclear.
[0007] In the prior art, there is no specific drug for the effective treatment of gastric adenocarcinoma, therefore, there is an urgent need for a pharmaceutical composition that can effectively treat

Method used

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  • Medicinal composition for regrouping human P43 protein and its application in medication
  • Medicinal composition for regrouping human P43 protein and its application in medication
  • Medicinal composition for regrouping human P43 protein and its application in medication

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] animal:

[0032] Source, species, strain: BALB / cA nude mice provided by Shanghai Experimental Animal Center, Chinese Academy of Sciences.

[0033] Certificate number: Shanghai Donghe Zhengzi No. 122.

[0034] Age: 35-40 days

[0035] Weight: 18-22g

[0036] Gender: Both male and female

[0037] Transplanted tumor:

[0038] Human gastric adenocarcinoma SGC-7901 nude mouse xenograft tumor was established by subcutaneous inoculation of human gastric adenocarcinoma SGC-7901 cell line in nude mice. The cell seeding volume is 1-3×10 6 , inoculated to form xenografts and then used in nude mice for 3 generations.

[0039] experimental method:

[0040] Take the tumor tissue in the vigorous growth period and cut it into 1.5mm 3 Left and right, under aseptic conditions, inoculated subcutaneously in the right armpit of nude mice. Use a vernier caliper to measure the diameter of the transplanted tumor in nude mice until the tumor grows to 100-300mm 3 Animals were then rand...

Embodiment 2

[0054] animal:

[0055] Source, species, strain: BALB / cA nude mice provided by Shanghai Experimental Animal Center, Chinese Academy of Sciences.

[0056] Certificate number: Shanghai Donghe Zhengzi No. 122.

[0057] Age: 35-40 days

[0058] Weight: 18-22g

[0059] Gender: Both male and female

[0060] Number of animals in each group: 10 in the negative control group and 5 in the treatment group.

[0061] Transplanted tumor:

[0062] Human gastric adenocarcinoma SGC-7901 nude mouse xenograft tumor was established by subcutaneous inoculation of human gastric adenocarcinoma SGC-7901 cell line in nude mice. The cell seeding volume is 1-3×10 6 , inoculated to form xenografts and then used in nude mice for 3 generations.

[0063] experimental method:

[0064] Take the tumor tissue in the vigorous growth period and cut it into 1.5mm 3 Left and right, under aseptic conditions, inoculated subcutaneously in the right armpit of nude mice. Use a vernier caliper to measure the di...

Embodiment 3

[0078] animal:

[0079] Source, species, strain: BALB / cA nude mice provided by Shanghai Experimental Animal Center, Chinese Academy of Sciences.

[0080] Certificate number: Shanghai Donghe Zhengzi No. 122.

[0081] Age: 35-40 days

[0082] Weight: 18-22g

[0083] Gender: Both male and female

[0084] Number of animals in each group: 10 in the negative control group and 5 in the treatment group.

[0085] Transplanted tumor:

[0086] Human gastric adenocarcinoma SGC-7901 nude mouse xenograft tumor was established by subcutaneous inoculation of human gastric adenocarcinoma SGC-7901 cell line in nude mice. The cell seeding volume is 1-3×10 6 , inoculated to form xenografts and then used in nude mice for 3 generations.

[0087] experimental method:

[0088] Take the tumor tissue in the vigorous growth period and cut it into 1.5mm 3 Left and right, under aseptic conditions, inoculated subcutaneously in the right armpit of nude mice. Use a vernier caliper to measure the di...

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Abstract

The invention provides a pharmaceutical composition used for treating gastric adenocarcinoma, which includes p43 protein and pharmaceutically acceptable carrier, wherein the pharmaceutical composition contains no paclitaxel. The invention also provides the usage of the p43 protein in gastric adenocarcinoma treatment.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gastric adenocarcinoma, and further relates to a pharmaceutical composition containing p43 protein and its use in treating gastric adenocarcinoma. Background technique [0002] Malignant tumors are the enemy that threatens human health. The medical field mainly adopts the method of killing cancer cells, namely: surgery, chemotherapy, radiotherapy, etc. for the treatment of malignant tumors. These methods also damage normal cells while killing cancer cells, and easily make tumor cells develop drug resistance. Therefore, people have been exploring a cancer treatment method that can specifically kill tumor cells without damaging normal cells, and at the same time, it is not easy to make tumors resistant to drugs. New drugs for the treatment of tumors are emerging in an endless stream. In recent years, with the continuous improvement of the research level of genetic engineering in molecul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P35/00
CPCA61K38/16A61P35/00
Inventor 刘大涛朱曦王嬿胡林达谭小钉
Owner SHANGHAI SINE PHARMA LAB
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