Medicine micropill and its prepn process

A technology for pellets and Wenxin, which is applied in the field of Wenxin pellets and its preparation technology, can solve the problems of unfavorable diabetic and obese patients taking, the Wenxin granules have a bad taste, and are easy to absorb moisture and soften, and achieve disintegration and melting. Excellent properties, low hygroscopicity and stable drug release

Inactive Publication Date: 2007-12-19
高志昂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems and deficiencies of the above-mentioned Wenxin Granules, such as poor taste, easy moisture absorption, softening, agglomeration and mildew, and the use of sucrose in the preparation molding, it is not conducive to diabetes and obese patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The components and the parts by weight of each component included in the formula that the Wenxin pellets provided by the present embodiment are as follows:

[0026] Codonopsis 900;

[0027] Polygonatum 1200;

[0028] Sanqi 180;

[0029] Amber 120;

[0030] Gansong 600;

[0031] The preparation method of Wenxin pellets provided by the present embodiment is as follows:

[0032] 1) get the amber powder of described amount and become fine powder for subsequent use;

[0033] 2) Appropriately crush the amount of nard pine, add 6 times the amount of water, soak for 30 minutes, distill and extract the volatile oil, the volatile oil is clathrated with 50 parts by weight of β-cyclodextrin, dried for later use, and the distilled aqueous solution is collected in another device ,spare;

[0034] 3) In the amount of notoginseng powder into a coarse powder, reflux extraction with 8 times the amount of 80% ethanol twice, each time for 2 hours, combine the alcohol extract, filter, ...

Embodiment 2

[0047] The components and the parts by weight of each component included in the formula that the Wenxin pellets provided by the present embodiment are as follows:

[0048] Codonopsis 700;

[0049] Polygonatum 1400;

[0050] Sanqi 140;

[0051] Amber 140;

[0052] Gansong 500;

[0053] The preparation method of Wenxin pellets provided by the present embodiment is as follows:

[0054] 1) get the amber powder of described amount and become fine powder for subsequent use;

[0055] 2) Appropriately crush the amount of nard pine, add 8 times the amount of water, soak for 60 minutes, distill and extract the volatile oil, the volatile oil is clathrated with 100 parts by weight of β-cyclodextrin, dried for later use, and the distilled aqueous solution is collected in another device ,spare;

[0056] 3) In the amount of notoginseng powder into a coarse powder, use 10 times the amount of 80% ethanol to reflux extract twice, each time for 2 hours, combine the alcohol extract, filter,...

Embodiment 3

[0074] The components and the parts by weight of each component included in the formula that the Wenxin pellets provided by the present embodiment are as follows:

[0075] Codonopsis 1100;

[0076] Polygonatum 1000;

[0077] Sanqi 220;

[0078] Amber 120;

[0079] Gansong 700;

[0080] The preparation method of Wenxin pellets provided by the present embodiment is as follows:

[0081] 1) get the amber powder of described amount and become fine powder for subsequent use;

[0082] 2) Properly crush the above amount of nard pine, add 10 times the amount of water, soak for 30 minutes, distill and extract the volatile oil, the volatile oil is clathrated with 180 parts by weight of β-cyclodextrin, dried for later use, and the distilled aqueous solution is collected in another device ,spare;

[0083] 3) Make coarse powder from the amount of Panax notoginseng powder, use 12 times the amount of 80% ethanol to reflux extract twice, each time for 2 hours, combine the alcohol extract...

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Abstract

The present invention relates to one kind of heart stabilizing medicine micropill and its preparation process. The heart stabilizing medicine micropill is prepared with Dangshen 700-1100 weight portions, solomoseal 1000-1400 weight portions, notoginseng 140-220 weight portions, amber 80-160 weight portions, spikenard 500-700 weight portions, starch 100-300 weight portions, and beta-cyclodextrin 50-200 weight portions. It has diameter smaller than 0.05 mm, good disintegrating and dissolving performance, fast acting, stable medicine release, high bioavailability and other advantages. It possesses the functions of benefiting qi, nourishing yin, eliminating palpitate and promoting blood circulation to disperse blood clots.

Description

technical field [0001] The invention relates to a pellet preparation and a preparation process thereof, in particular to a Wenxin pellet and a preparation process thereof. Background technique [0002] Wenxin Granules currently sold in the market meet the national standard WS of the State Drug Administration. 3 -205(x-029)-99(z), composed of Dangshen, Polygonatum, Panax notoginseng, amber, and Gansong five herbs, has the effects of nourishing qi and nourishing yin, calming palpitations and restoring pulse, promoting blood circulation and removing blood stasis. Clinically, it is mainly used for palpitations, restlessness, shortness of breath and fatigue, dizziness and palpitations, chest tightness and pain, arrhythmia, ventricular premature beats, atrial premature beats, etc. [0003] The formula of Wenxin Granules is as follows: Codonopsis 300g, Polygonatum 400g, Panax notoginseng 60g, Amber 40g, Gansong 200g. The preparation process of Wenxin Granules is as follows: the a...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/16A61P9/10A61P9/06A61K35/10
Inventor 高志昂梁起臣
Owner 高志昂
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