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Method for preparing medicine to treat atherosclerosis

A technology of atherosclerosis and composition, which is applied in the field of preparation of pharmaceutical compositions, and can solve the problems of unremarkable substantive features, simple preparation methods, undisclosed drug ratio relationship and preparation methods, etc.

Active Publication Date: 2007-10-03
JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tongsaimai Tablet, a drug for treating atherosclerosis, is a standard drug of the State Food and Drug Administration. The standard discloses the composition of the drug, but does not disclose the drug ratio relationship and preparation method; the application number is 03113176. Application of Saimai Extract in the Preparation of Drugs for the Treatment of Cerebral Stroke" discloses the composition and proportioning relationship of the drug, but there are defects such as simple preparation method and unremarkable substantive features

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Astragalus 420kg, Angelica 530kg, Codonopsis 420kg, Scrophulariaceae 530kg, Honeysuckle 420kg, Dendrobium 530kg, Achyranthes bidentata 420kg, Licorice 530kg;

[0152] A. Decoction: Add the raw material medicine into the multifunctional extraction tank, add 6 times the amount of water, heat and decoct for 0.5 hours, and start timing when the temperature in the pot reaches 100°C; filter to obtain filtrate I, and put it into the liquid storage tank for standby Add 4 times the amount of water to the dregs and decoct for 0.5 hour, filter, merge with filtrate I to obtain filtrate II, and discard the dregs;

[0153] B. Concentration: Input the filtrate II into the double-effect concentrator, control the temperature below 70°C, heat and concentrate at a vacuum degree of -0.05Mpa to a relative density of 1.10-1.29 at 50-60°C, and collect the thick paste I;

[0154] C, alcohol precipitation: take the thick paste I and put it in the alcohol precipitation tank, add ethanol until th...

Embodiment 2

[0158] Astragalus 530kg, Angelica 420kg, Codonopsis 530kg, Scrophulariae 420kg, Honeysuckle 530kg, Dendrobium 420kg, Achyranthes bidentata 530kg, Licorice 420kg;

[0159] A. Decoction: Add the raw material medicine into the multifunctional extraction tank, add 4 times the amount of water, heat and decoct for 2.5 hours, and start timing when the temperature in the pot reaches 100°C; filter to obtain filtrate I, and put it into the liquid storage tank for standby Add 2 times the amount of water to the dregs and decoct for 1.5 hours, filter, merge with filtrate I to obtain filtrate II, and discard the dregs;

[0160] B. Concentration: Input the filtrate II into the double-effect concentrator, control the temperature below 70°C, heat and concentrate at a vacuum degree of -0.05Mpa to a relative density of 1.10-1.29 at 50-60°C, and collect the thick paste I;

[0161] C, alcohol precipitation: take the thick ointment I and put it in the alcohol precipitation tank, add ethanol until t...

Embodiment 3

[0165] Astragalus 480kg, Angelica 480kg, Codonopsis 480kg, Scrophulariae 480kg, Honeysuckle 480kg, Dendrobium 480kg, Achyranthes bidentata 480kg, Licorice 480kg;

[0166] A. Decoction: Add the raw material medicine into the multifunctional extraction tank, add 5 times the amount of water, heat and decoct for 1.5 hours, and start timing when the temperature in the pot reaches 100°C; filter to obtain filtrate I, and put it into the liquid storage tank for standby Add 3 times the amount of water to the dregs, decoct for 1 hour, filter, and merge with filtrate I to obtain filtrate II, and discard the dregs;

[0167] B. Concentration: Input the filtrate II into the double-effect concentrator, control the temperature below 70°C, heat and concentrate at a vacuum degree of -0.05Mpa to a relative density of 1.10-1.29 at 50-60°C, and collect the thick paste I;

[0168] C, alcohol precipitation: take the thick paste I and put it in the alcohol precipitation tank, add ethanol until the al...

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PUM

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Abstract

A Chinese medicine for treating atherosclerosis is prepared from 8 Chinese-medicinal materials including astragalus root, Chinese angelica root, pilose asiabell root, honeysuckle flower, etc through decocting and filtering twice, collecting liquid, concentrating, depositing in alcohol, taking supernatant, filtering for recovering alcohol, concentrating, drying, adding auxiliaries, and shaping.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical composition, in particular to a preparation method of a pharmaceutical composition for treating atherosclerosis. Background technique [0002] Arteriosclerosis is a general term for degenerative and proliferative lesions in which the arterial wall thickens, hardens, and the lumen shrinks. Atherosclerosis is a common type of arteriosclerosis and is the main cause of myocardial infarction and cerebral infarction. Tongsaimai Tablet, a drug for treating atherosclerosis, is a standard drug of the State Food and Drug Administration. The standard discloses the composition of the drug, but does not disclose the drug ratio relationship and preparation method; the application number is 03113176. The invention application of "Application of Saimai Extract in the Preparation of Drugs for Treating Cerebral Apoplexy" discloses the composition and proportioning relationship of the drugs, but there are ...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/28A61K9/48A61P9/10
Inventor 夏月陈荣明李吉峰殷书梅束建清周树云王宓
Owner JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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