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Process for extracting separating arecoline in scale

A technology of arecoline and a new process, which is applied in the field of large-scale extraction and separation of drugs, and can solve the problems of high extraction cost, long process, and laboriousness

Inactive Publication Date: 2007-09-05
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Make a general survey of the above-mentioned extracting arecoline method and have the following defects: the first, what extract is used is that the high-concentration alcohol extraction cost is higher; In the process of dissolving and filtering, because there are many insoluble components in the extract in acidic conditions, it brings a lot of trouble and labor to the filtering; fourth, the extraction rate is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 20 kilograms of betel nuts, crush them into coarse powder, weigh 1.5 kilograms of medicinal powder, mix it with 0.5% 800ml dilute hydrochloric acid, put it into a percolation column, and then elute it with hydrochloric acid of this concentration. 8 times the amount of elution until the arecoline in the betel nut is completely extracted. The judgment standard is to add concentrated ammonia water dropwise to the eluent until there is no obvious white precipitate in the eluent. The collected solution was filtered with cotton cloth, and after filtering, 1200 ml of the eluent was adjusted with about 30 ml of ammonia water to make the pH of the eluent reach 8. Afterwards, extract with chloroform, and extract with 400 ml, 300 ml, and 200 ml of chloroform for every 1200 ml, respectively. The combined extracts were concentrated under normal pressure, and the total alkaloids were obtained after the concentrate was volatilized to a constant volume. Then it is dissolved with...

Embodiment 2

[0018] Take 20 kilograms of betel nuts, crush them into coarse powder, weigh 1.5 kilograms of medicinal powder, mix it with 0.7% 700ml dilute hydrochloric acid, put it into a percolation column, and then elute it with hydrochloric acid of this concentration. 9 times the amount of elution until the arecoline in the betel nut is completely extracted. The judgment standard is to add concentrated ammonia water dropwise to the eluent until there is no obvious white precipitate in the eluent. The collected solution was filtered with cotton cloth, and after filtering, 1200 ml of the eluent was adjusted with about 40 ml of ammonia water to make the pH value of the eluent reach 9. Afterwards, extract with chloroform, and extract with 400 ml, 300 ml, and 200 ml of chloroform for every 1200 ml, respectively. The combined extracts were concentrated under normal pressure, and the total alkaloids were obtained after the concentrate was volatilized to a constant volume. Then dissolve it wi...

Embodiment 3

[0020] Take 20 kilograms of betel nuts, crush them into coarse powder, weigh 1.5 kilograms of medicinal powder, mix it with 1.0% 600ml dilute hydrochloric acid, put it into a percolation column, and then elute it with hydrochloric acid of this concentration. 10 times the amount of elution until the arecoline in the betel nut is completely extracted. The judgment standard is to add concentrated ammonia water dropwise to the eluent until there is no obvious white precipitate in the eluent. The collected solution was filtered with cotton cloth, and after filtering, 1200 ml of the eluent was adjusted with about 45 ml of ammonia water to make the pH value of the eluent reach 10. Then extract with chloroform, and extract with 400 ml, 300 ml, and 200 ml of chloroform for each 1200 ml respectively. The combined extracts were concentrated under normal pressure, and the total alkaloids were obtained after the concentrate was volatilized to a constant volume. Then dissolve it with 70% ...

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Abstract

A process for extracting and separating arecaline in batches includes such steps as breaking areca, mixing with diluted hydrochloric acid, percolating, eluting with diluted hydrochloric acid, regulating pH=8-10, extracting in chloroform, concentrating, dissolving in high-concentration alcohol, filtering and recovering alcohol.

Description

technical field [0001] The invention belongs to a new technology for large-scale extraction and separation of medicines. Background technique [0002] Because betel nut contains a variety of alkaloids, mainly arecoline, there are also arecoline, demethyl arecoline, arecoline, and homoarecoline. Arecoline can be dissolved in any concentration of ethanol, but also in fat-soluble solvents, while arecoline is only soluble in low-concentration ethanol, so high-concentration ethanol is used for extraction. In the extraction process, a large amount of high-concentration alcohol is required as the eluent, and after the eluent is concentrated under reduced pressure, the concentrated solution takes a long time to volatilize and become an extract. Afterwards, the extract is acidified and dissolved with an appropriate amount of dilute acid distilled water. Because the alcohol extraction ability is relatively strong, many other non-purpose components in the betel nut are also extracted ...

Claims

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Application Information

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IPC IPC(8): C07D211/78
Inventor 张继瑜李剑勇张占锋周绪正魏小娟李金善
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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