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Mediators of hedgehog signaling pathways, compositions and uses related thereto

A method and compound technology, applied in the directions of active ingredients of heterocyclic compounds, cosmetic preparations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2007-08-01
CURIS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is more likely that this causes secondary signaling leading to the synthesis of parathyroid hormone-related protein (PTHrP) in the periarticular perichondrium

Method used

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  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto

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Embodiment

[0603] Having generally described this invention, it can be more readily understood by reference to the following examples, which are included for purposes of illustration only of certain aspects and embodiments of the invention, and are not intended to be limiting of the invention. .

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Abstract

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g.,to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Description

[0001] This application is a divisional application of the parent application with application number 02818679.6. The application date of the parent application is July 29, 2002; the title of the invention is "Hedgehog signal transduction pathway mediator, its related composition and application". Background of the invention [0002] Schema formation is the activity by which embryonic cells form different tissues arranged in an orderly space. Physiological complexity in higher organisms arises during embryogenesis through the interplay of the cell's own lineage and signals external to the cell. Inducible interactions are essential for embryonic patterning in vertebrate development, from the earliest establishment of body plans, to patterning of organ systems and generation of distinct cell types during tissue differentiation (Davidson, E., (1990 ) Development 108:365-389; Gurdon, J.B., (1992) Cell 68:185-199; Jessell, T.M. et al., (1992) Cell 68:257-270). The effects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D405/12C07D235/18C07D401/12C07D471/04C07D409/12A61K31/395A61K31/4184A61K31/423A61K31/42A61K8/49A61K
Inventor L·鲁宾O·M·吉谢里特S·普里斯E·A·博伊德
Owner CURIS INC
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