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Antineoplastic chemotherapy medicine composition, and its application

A chemotherapy drug and anti-tumor technology, applied in anti-tumor drugs, drug combinations, diseases, etc.

Inactive Publication Date: 2007-07-25
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The catechin component with low cytotoxicity, epigallocatechin gallate (epigallocatechin gallate, EGCG) is a main monomer component obtained by extracting tea polyphenols from green tea in my country and further separating them. There have been many reports of strong anti-tumor activity, but there has been no report on the multidrug resistance of catechins against tumors

Method used

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  • Antineoplastic chemotherapy medicine composition, and its application

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Embodiment

[0043] Embodiment: an antitumor chemotherapeutic drug composition, its active ingredient is made up of following two kinds of substances:

[0044] Epigallocatechin gallate;

[0045] Mitoxantrone;

[0046] Wherein, the weight ratio of epigallocatechin gallate to mitoxantrone is 100:1˜1:5.

[0047] The anti-tumor chemotherapeutic drug composition of this embodiment is used as a chemotherapeutic drug for the treatment of breast cancer and leukemia, wherein epigallocatechin gallate has the effect of reversing the multidrug resistance of anti-tumor chemotherapeutic drugs, and can improve breast cancer cells and leukemia cells. Sensitivity of cancer cells to mitoxantrone and increasing the therapeutic effect of mitoxantrone on tumors.

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Abstract

An antineoplastic medicinal composition used to prepare the medicines for treating breast cancer and leukemia contains the epigallocatechin gallate and mitoxantrone in weight ratio of (1-2000): (1-5).

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a composition of epigallocatechin gallate and mitoxantrone and its medical application. Background technique [0002] Multidrug resistance (MDR) refers to the generation of cross-resistance to multiple antitumor drugs with different structures and mechanisms of action when cancer cells are exposed to one antitumor drug and develop drug resistance. Cancer patients often develop multidrug resistance after drug chemotherapy. Multidrug resistance is the main reason for the failure of cancer chemotherapy, and it is also one of the problems that need to be solved urgently in cancer chemotherapy. At present, there is no effective drug to overcome the problem of drug resistance. For tumors that develop drug resistance, in order to achieve the original curative effect, the dosage of drugs needs to be increased, but patients often cannot tolerate it, which eventually leads to the fail...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P35/00A61P35/02A61P15/14A61K31/136
Inventor 李新平张玉武史群芳申付文黄璐朱爱思余海洋李岱白利雄赵胤晟
Owner SUZHOU UNIV
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