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Medicine composition for treating neurosis

A technology of composition and medicine, applied in the field of pharmaceutical composition for the treatment of neurosis, can solve the problems of narrow application range and single effect in clinical application, and achieve less adverse reactions, good therapeutic effect and less side effects

Inactive Publication Date: 2009-06-03
刘超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the scope of adaptation is relatively narrow, and the traditional Chinese medicine prescription with single effect can not meet the needs of clinical application far away.

Method used

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  • Medicine composition for treating neurosis
  • Medicine composition for treating neurosis
  • Medicine composition for treating neurosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: The experiment of the medicine of the present invention against ptosis caused by reserpine in mice

[0039] experimental method

[0040] The Department of Pharmacology, School of Basic Medicine, Hebei Medical University used 40 Kunming mice, half male and half male, randomly divided into blank control group, positive drug control group, experimental group 1 and experimental group 2, a total of 4 groups. Above each group all gavages and gives the liquid of volume 0.2ml / 10g body weight, and blank control group only feeds water; Positive drug control group intraperitoneally injects imipramine 25mg / kg, and experimental group gives medicated powder of the present invention, according to 1.0g / kg, respectively. Oral administration of 2.0g / kg (thereby divided into experimental group 1 and experimental group 2), medication for 7 days; 1 hour before the last administration, first observe whether there is ptosis, and then immediately inject reserpine 0.5mg / kg subcuta...

Embodiment 2

[0048] Embodiment 2: The medicine of the present invention is to prolonging the impact of pentobarbital sodium-induced sleep time in mice

[0049] experimental method

[0050] Fifty Kunming mice, half male and half male, were randomly divided into five groups: blank control group, positive control group, and experimental group. Above each group all gavages and gives the liquid of volume 0.2ml / 10g body weight, and blank control group only feeds water, and positive control group intraperitoneally injects medicine imipramine 25mg / kg, and experimental group gives medicated powder of the present invention, according to 0.5g / kg, respectively. 1.0g / kg, 2.0g / kg orally (thereby divided into experimental group 1, experimental group 2, experimental group 3 three groups) for 3 days; 30 minutes after the last administration, pentobarbital sodium 50mg / kg Intraperitoneal injection, taking the disappearance of righting reaction as the sleep index, observe the effects of each group on prolong...

Embodiment 3

[0055] Embodiment 3: acute toxicological experiment of the medicine of the present invention.

[0056] experimental method

[0057] Get 20 Kunming mice, body weight 18-22g, male and female half and half, get 30g of the medicinal powder of the present invention, add water to 75mL, grind and be mixed with 40% suspension, gavage by 0.4ml / 10g body weight, administer altogether 3 times, the dosing interval was 2 hours. After the first administration, the mice searched for food, drank water, and moved normally; after the second administration, the mice squatted with their eyes closed, and their reactivity to stimuli decreased. 1.5 hours after the administration, 9 / 20 of them had loose stools. After the third administration, the mice appeared listless, and about 1 hour after the administration, all the mice had loose stools. The activities and behaviors of all mice returned to normal on the second day after administration. A total of 7 days of observation, no death occurred. The ...

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Abstract

The present invention discloses a kind of neurosis treating medicine composition, which is prepared bupleurum root, kudzu vine root, corydalis tuber, white peony root, cassia twig and other nine kinds of Chinese medicinal materials in certain weight proportion. The medicine composition may be used in preparing different preparations for treating different types of neurosis, and has high curative effect and fast acting. The present invention is suitable for industrial production.

Description

technical field [0001] The present invention relates to a preparation for medical use, in particular to a pharmaceutical composition especially suitable for the treatment of neurosis. technical background [0002] Neurosis is a common disease, which is usually a series of mental, nervous and physical symptoms caused by temporary dysfunction of brain activity caused by the interaction of various factors such as personality, psychology and society. Corresponding pathological signs were not found. The course of neurosis is protracted, and the incidence rate is increasing year by year. The World Health Organization estimates based on survey data from various countries that the incidence of neurosis is about 5% to 8%. The incidence rate in western developed countries is generally 10% to 20%. Neurosis is prevalent in the Chinese population, and its incidence rate should be higher than that in western developed countries. The common types of clinical neurosis are: neurasthenia, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/8888A61K36/725A61K36/71A61K36/66A61K36/54A61K36/536A61K36/484A61K36/48A61K36/233A61K36/076A61K35/56A61K35/02A61P25/00A61P25/20A61P25/22A61P25/24A61K35/618
Inventor 刘超刘坤申
Owner 刘超
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