Cannabidiol preparations and its uses
a technology of cannabis and preparations, applied in the field of cannabis preparations, can solve the problems of unsuitable pharmaceutical formulations for crude products, and achieve the effects of poor insulin control, low back pain, and high blood pressur
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example 1
Process for Production of a Botanically Derived Purified CBD Preparation
Overview of the Process
[0216]The following describes the production of the botanically derived purified CBD (>98% w / w) which has a known and constant composition which was used in the Examples below.
[0217]Plant material harvested from the Cannabis sativa L. plant was subjected to liquid carbon dioxide extraction, to produce a botanical extract containing CBD in addition to other cannabinoids and non-cannabinoid components. The extract was then further purified by a solvent crystallization method to yield botanically derived purified CBD. The crystallization process specifically removed other cannabinoids and plant components to yield greater than 98% (w / w) CBD.
[0218]Both the botanical starting material and the botanical extract may be controlled by specifications. An exemplary botanical starting material specification for decarboxylated Cannabis plant material is described in Table 1.1 below. In some embodiments...
example 2
ation of the Stereochemistry of the THC Present in Botanically Derived Purified CBD Preparations
[0238]As described in Example 1 above, the cannabinoid THC is present in the botanically derived purified CBD preparation at an amount of not more than 0.1% (w / w). In certain embodiments the THC is present at an amount of 0.02 to 0.1% w / w.
[0239]The THC molecule may exist as four distinct chiral forms as shown in FIG. 2. THC has 2 stereocenters which in turn enable the existence of 4 stereoisomers: (+)-trans-THC; (−)-trans-THC; (+)-cis-THC and (−)-cis-THC. However, THC is known to be produced in nature as the (−)-trans-THC isoform (Hollister, 1970).
[0240]The following examples describe studies undertaken to elucidate the stereoisomers which are produced by the high-CBD plant used to prepare the exemplary botanically derived purified CBD preparation which is described in Example 1.
Detection and Quantification of Trace Levels of THC in Botanically Derived Purified CBD
[0241]Ultra Performance ...
example 3
ation of the Ratio of Trans-THC to Cis-THC Present in Botanically Derived Purified CBD Preparations
[0254]As is described in Example 1, the production of a botanically derived purified CBD preparation is a complex process containing several steps resulting in different types of intermediate materials. Firstly, the high-CBD plants are harvested, dried and baled to produce Botanical Raw Material, (BRM). The baled material is pelleted, extracted using liquid CO2, refined during the winterization process and purified during the crystallization process. The CBD BRM starting material contains a number of different cannabinoid impurities present alongside the principal compound CBD.
[0255]The present example sought to determine the ratio of trans-THC to cis-THC throughout the production process of the botanically derived purified CBD preparation.
[0256]The retention time of trans-THC and cis-THC is different using reverse phase chromatography as shown in FIG. 5. The polarity of these two comp...
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