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Cannabidiol preparations and its uses

a technology of cannabis and preparations, applied in the field of cannabis preparations, can solve the problems of unsuitable pharmaceutical formulations for crude products, and achieve the effects of poor insulin control, low back pain, and high blood pressur

Pending Publication Date: 2021-02-25
GW RES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such crude products are unsuitable for use in pharmaceutical formulations.

Method used

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  • Cannabidiol preparations and its uses
  • Cannabidiol preparations and its uses
  • Cannabidiol preparations and its uses

Examples

Experimental program
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Effect test

example 1

Process for Production of a Botanically Derived Purified CBD Preparation

Overview of the Process

[0216]The following describes the production of the botanically derived purified CBD (>98% w / w) which has a known and constant composition which was used in the Examples below.

[0217]Plant material harvested from the Cannabis sativa L. plant was subjected to liquid carbon dioxide extraction, to produce a botanical extract containing CBD in addition to other cannabinoids and non-cannabinoid components. The extract was then further purified by a solvent crystallization method to yield botanically derived purified CBD. The crystallization process specifically removed other cannabinoids and plant components to yield greater than 98% (w / w) CBD.

[0218]Both the botanical starting material and the botanical extract may be controlled by specifications. An exemplary botanical starting material specification for decarboxylated Cannabis plant material is described in Table 1.1 below. In some embodiments...

example 2

ation of the Stereochemistry of the THC Present in Botanically Derived Purified CBD Preparations

[0238]As described in Example 1 above, the cannabinoid THC is present in the botanically derived purified CBD preparation at an amount of not more than 0.1% (w / w). In certain embodiments the THC is present at an amount of 0.02 to 0.1% w / w.

[0239]The THC molecule may exist as four distinct chiral forms as shown in FIG. 2. THC has 2 stereocenters which in turn enable the existence of 4 stereoisomers: (+)-trans-THC; (−)-trans-THC; (+)-cis-THC and (−)-cis-THC. However, THC is known to be produced in nature as the (−)-trans-THC isoform (Hollister, 1970).

[0240]The following examples describe studies undertaken to elucidate the stereoisomers which are produced by the high-CBD plant used to prepare the exemplary botanically derived purified CBD preparation which is described in Example 1.

Detection and Quantification of Trace Levels of THC in Botanically Derived Purified CBD

[0241]Ultra Performance ...

example 3

ation of the Ratio of Trans-THC to Cis-THC Present in Botanically Derived Purified CBD Preparations

[0254]As is described in Example 1, the production of a botanically derived purified CBD preparation is a complex process containing several steps resulting in different types of intermediate materials. Firstly, the high-CBD plants are harvested, dried and baled to produce Botanical Raw Material, (BRM). The baled material is pelleted, extracted using liquid CO2, refined during the winterization process and purified during the crystallization process. The CBD BRM starting material contains a number of different cannabinoid impurities present alongside the principal compound CBD.

[0255]The present example sought to determine the ratio of trans-THC to cis-THC throughout the production process of the botanically derived purified CBD preparation.

[0256]The retention time of trans-THC and cis-THC is different using reverse phase chromatography as shown in FIG. 5. The polarity of these two comp...

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Abstract

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is C21H30O2 and its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in the Cannabis sativa L. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and / or functional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

Description

FIELD OF THE INVENTION[0001]Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is C21H30O2 and its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in the Cannabis sativa L. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents.[0002]The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present.[0003]Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD trea...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/05A61K31/352A61K36/185A61P25/08A61P25/18
CPCA61K31/05A61K31/352A61P25/18A61P25/08A61K36/185A61K45/06A61P25/00B01D11/0288B01D11/0203B01D9/0013A61P25/10A61P25/12A61P25/16A61P25/28A61P25/30A61P25/32A61K9/0019A61K9/0053A61K9/0073A61K9/7023A61K2236/33A61K2236/51
Inventor GUY, GEOFFREYKNAPPERTZ, VOLKERWHALLEY, BENJAMINWOOLLEY-ROBERTS, MARIEBRODLE, JAMESLACH-FALCONE, KATARZYNASUTTON, ALANGRAY, ROYSTONRANA, ROHINI RAJYALAXMI
Owner GW RES LTD
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