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Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to corneal tissue

a technology of photochemical and corneal tissue, applied in the field of method and apparatus for the delivery of photochemical (cross-linking) treatment to corneal tissue, can solve the problems of irregular myopically shaped cornea, unsuitable patient-friendly procedure, and several significant limitations of the current prior art cxl process

Inactive Publication Date: 2012-09-20
SEROS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current prior art CXL process has several significant limitations.
Debridement is painful to the patient, but more importantly, over 70% of the adverse events reported from CXL can be traced to debridement.
CXL takes, on average, one hour per eye, which is not considered a patient-friendly procedure, especially with a speculum remaining in the patient's eye during the entire procedure.
However, following CXL treatment by such prior art methods, the keratoconic patient continues to have an irregular myopically shaped cornea.

Method used

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  • Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to corneal tissue
  • Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to corneal tissue
  • Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to corneal tissue

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Embodiment Construction

[0022]The present inventions generally relate to various methods and embodiments to rapidly dose ocular tissue with photo-chemical exposures. Specifically, this involves a trans-epithelial drug transfusion, such as riboflavin (R / F) formulations, into the collagen tissue in the corneal mid-stroma region. Additionally, these methods and embodiments also provide for photonic (typically UVA) delivery to the cornea. The R / F so delivered to corneal collagen tissue (by micro-injection) is then rapidly activated with UVA irradiation thereby inducing cross-linking of the collagen tissue.

[0023]The embodiments providing treatment for the cornea as described herein include various applications of micro-needle array (MNA) technology to provide rapid, sub-surface delivery of R / F into the corneal ocular tissue. In such methods of treatment, the MNA's may be inserted into corneal tissue through penetration of MNA's into the cornea. A R / F formulation can be delivered into the tissue through the appl...

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Abstract

Systems and methods for delivering and infusing formulations containing riboflavin or its analogues, or other ophthalmic formulations, into corneal tissue are disclosed. Systems and methods are further disclosed to cross-link the corneal tissue through exposure to UVA irradiation. The systems and methods for formulation delivery employ micro-needle array delivery devices.

Description

[0001]This application claims the benefit of U.S. Provisional Patent Application No. 61 / 443,191 filed on Feb. 15, 2011 and is incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]This invention is directed to designs and methods for delivering and infusing dosage forms containing riboflavin or its analogues, or other ophthalmic formulations, into ocular tissue (such as the cornea) using rapid and minimally invasive methods. In general, the devices created to perform these tasks have capabilities that provide a micro-needle array drug delivery method combined with a high intensity photonic excitation of ocular tissue. As a result, such devices provide effective crosslinking of collagen ocular tissue. Additionally, the embodiments of the present invention herein described are directed at the treatment of refractive myopia and other conditions (such as presbyopia) wherein re-shaping of the cornea is required to obtain normal vision. The corneal reshaping is done with a the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M37/00A61P27/02A61M5/00A61K31/525
CPCA61F9/0017A61F9/0079A61N5/062A61K41/0038A61K31/525A61P27/02A61K9/0051A61K41/0057
Inventor HEREKAR, SATISH V.MANCHE, EDWARD E.EATON, DONALD J.
Owner SEROS MEDICAL
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