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Attenuated salmonella enterica serovar paratyphi a and uses thereof

Active Publication Date: 2012-02-02
MARYLAND UNIV OF
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0021]The present invention also includes a pharmaceutical formulation comprising one or more of the attenuated Salmonella Paratyphi A strains of the present invention. Preferably the pharmaceutical formulations are oral pharmaceutical formulations.
[0022]The present invention further includes a method of inducing an immune response in a subject, comprising administering an immunologically-effective amount of a pharmaceutical formulation of the present invention to a subject. Preferably, the immune response is a protective immune response.
[0023]The immunologically-effective amount of the pharmaceutical formulation contains about 102 cfu to about 1010 cfu, more preferably about 106 cfu to about 109 cfu, of the attenuated S. Paratyphi A strain within the pharmaceutical formulation.

Problems solved by technology

Typhi, the former can nevertheless result in full-blown enteric fever with an assortment of complications and, if untreated or improperly treated, can result in death.

Method used

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  • Attenuated salmonella enterica serovar paratyphi a and uses thereof
  • Attenuated salmonella enterica serovar paratyphi a and uses thereof
  • Attenuated salmonella enterica serovar paratyphi a and uses thereof

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Experimental program
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Embodiment Construction

A. Attenuated S. Paratyphi A Strains

[0036]The present invention relates to an attenuated S. Paratyphi A strain. Such attenuated S. Paratyphi A strains may be used to induce an immune response in a subject without causing disease in the subject.

[0037]The S. Paratyphi A strain used as the starting material of the present invention may be any S. Paratyphi A strain and the identity of the strain is not critical. Preferred S. Paratyphi A strains include S. Paratyphi A 9150 strain.

[0038]The S. Paratyphi A strains of the present invention are attenuated. As used herein, attenuated strains of S. Paratyphi A are those that have a reduced, decreased, or suppressed ability to cause disease in a subject, or those completely lacking in the ability to cause disease in a subject. Attenuated strains may exhibit reduced or no expression of one or more genes, may express one or more proteins with reduced or no activity, may exhibit a reduced ability to grow and divide, or a combination of two or more...

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Abstract

The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.

Description

RELATED APPLICATIONS[0001]The present application is a continuation-in-part of U.S. patent application Ser. No. 12 / 091,929, filed Apr. 28, 2008, which claims the benefit of International Application No. PCT / US06 / 42148, filed Oct. 30, 2006, and the benefit of U.S. Provisional Application No. 60 / 731,349, filed Oct. 28, 2005. The entire disclosure and teachings of the above-referenced Applications are incorporated herein by reference.STATEMENT OF FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT[0002]This invention was made with government support under NIH Grant No. A1029471 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND OF THE INVENTION[0003]Enteric fever caused by members of the genus Salmonella, including typhoid and paratyphoid fevers, continues to constitute a significant disease and mortality burden among populations in developing countries (Lancet 2005; 366:749-762) and represents a notable risk for travelers (Lancet Infec...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/195A61P37/04A61K39/385
CPCA61K39/0275C12N1/36A61K2039/522A61K2039/6068A61P37/04Y02A50/30
Inventor VINDURAMPULLE, CHRISTOFERBARRY, EILEEN M.LEVINE, MYRON M.GALEN, JAMES
Owner MARYLAND UNIV OF
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