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Cytochrome P450 enzyme complexes and methods of treatment using the same

a technology of cytochrome p450 and enzyme complex, which is applied in the field of living organism treatment methods and compositions, can solve the problems of population that is left without the ability to defend adequately against xenobiotics, unavoidable p450 inhibitors, etc., and achieves the effects of enhancing p450, enhancing quality of life, and nutritious

Inactive Publication Date: 2010-05-27
NONOMURA ARTHUR M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]Thus, a P450:FMN enzyme complex, with more than one FMN molecule in the complex, results in a novel composition of matter (such as in the form of a food supplement, a dietary supplement, a beverage, a topical formulation, or a pill) that assists the body in detoxifying xenobiotics. The direct connection of FMN, for example, to fortify these enzyme complexes, has not been made previously. This invention thus provides methods of detoxification by administering compositions that are selected for accelerating specific activity. These formulations enhance P450 in subcellular nanoarrays. By means of compositions comprised of inducers that are selected for regeneration, the present invention introduces methods of activating repressed nanoscopic structures.
[0011]For these reasons, it would be desirable to provide novel methods and compositions for the purpose of fortifying the complexes in humans and other living organisms. It would be particularly desirable if such methods and compositions were able to induce these complexes in specific tissues. The present invention further provides convenient methods resulting in fortification of these complexes for animal and human therapy. It is desirable that the methods and compositions of the present invention promote eradication of undesirable compounds in a manner that enhances the quality of life. It would be further desirable to provide palatable treatments that are nutritious and broadly effective. To that end, preferably, the compositions of an embodiment of the present invention are sweet-tasting, as a rewarding means that encourage daily upkeep of the enzymes complexes.
[0019]As another specific aspect, the present invention provides methods for dietary supplements to come to the defense of humans against harmful xenobiotics whilst improving nutrition, particularly, in sweeteners.

Problems solved by technology

On the other hand, inhibitors of P450 are also unavoidable.
Upon exposure to the strongest inhibitors, the population is left without the ability to defend adequately against xenobiotics.

Method used

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  • Cytochrome P450 enzyme complexes and methods of treatment using the same
  • Cytochrome P450 enzyme complexes and methods of treatment using the same

Examples

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Effect test

example 1

[0063]

First Exemplary Composition: FMNConcentration per doseCompositionBroad RangeNarrow RangeFMN0.01-50 mg   3-5 mgCod liver oil 1-2500 mg100-1000 mgSecond Exemplary Composition: DrinkConcentration per100 ml doseCompositionBroad RangeNarrow RangeXylose0.1-1%1-1000 gFMN1-1000 ppm1 mcg-5 mgThird Exemplary CompositionConcentrationComponentBroad RangeNarrow RangeFMN0.01-20 mg 1-5 mgAnalgesics 1-2000 mg5-100 mgFourth Exemplary CompositionConcentrationCompositionBroad RangeNarrow RangeFMN  1-5 mg 2-5 mgNADP10-100 mg10-50 mgBicarbonateexcipientexcipientFifth Exemplary CompositionComponentDoseRangeFMN5 mg1-5 mgLiver extract1 mg10 mcg-2 gSixth Exemplary Composition: DrinkConcentrationCompositionBroad RangeNarrow RangeFMN1 mcg-50 mg10 mcg-5 mgD-Xylose1-1000 g5-50 gEtOHexcipientexcipientCarbon dioxideexcipientexcipientWaterexcipientexcipientSeventh Exemplary Composition: Natural SweetenerSuitable for people with diabetesConcentrationCompositionBroad RangeNarrow RangeFolate 1-100 mcg 1-3 mcgFM...

example 2

[0064]The following example illustrates an application of human P450 compositions according to the present invention. Procedures followed previously described methods, e.g., U.S. Pat. No. 6,020,288; M. Markwell, et al., Methods of Enzymology 72:296-303 (1981); C. A. Mihaliak, et al., Methods in plant biochemistry 19:261-279 (1993); R. Donaldson, et al., Arch. Biochem. Biophys. 152:199-215 (1972); and M. Persans, et al., Plant Physiol. 109:1483-1490 (1995)). The results demonstrate the efficacy of the methods and compositions of the present invention for the enhancement of P450 enzyme complexes.

[0065]Methods. CPR substrates have been assayed on various tissues (e.g., U.S. Pat. No. 6,020,288); therefore, response to human CPR (hCPR) was examined under controlled conditions on live index organisms. The direct effects of substrates on hCPR were measured by preparation of microsomes for quantification against CPR and Cc. Controls included equal concentrations of each individual treatment...

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Abstract

The present invention provides methods and compositions for balancing electron reduction potentials of formulations in a manner that reduces susceptibility to changes from xenobiotics. The present invention also provides novel compositions of matter based on structuring from a mobile nucleotide integral to its architecture.

Description

[0001]This application is a divisional of U.S. Ser. No. 11 / 312,056 filed Dec. 20, 2005, which claims priority of U.S. provisional application Ser. No. 60 / 638,918 filed Dec. 23, 2004, the disclosures of which are hereby incorporated by reference.BACKGROUND OF THE INVENTION[0002]The present invention relates generally to methods and compositions for treating living organisms:[0003]Upon utilization of a nanoscalar particle to achieve a practical purpose, its design and replication defines the field of nanotechnology. Indeed, over the past decade, inventions of biomaterials have focused on synthesis, while purposeful in vivo applications have gone wanting. Developments have resulted from the fabrication of novel architectures that range from Bucky Balls to octahedral DNA. Cytochromes offer some special nanometric advantages that are realized as a result of architecture elucidated within the current invention[0004]A diversity of cytochromes present possibilities for multitudes of combina...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N9/96
CPCA23L1/3008A23L1/3012A23V2002/00C12N9/0077A61K31/7072A61K35/60A23V2200/328A23V2250/638A23V2250/264A61K2300/00A23L33/12A23L33/13
Inventor NONOMURA, ARTHUR M.
Owner NONOMURA ARTHUR M
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