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LOOP PEPTIDE AND TGF alpha FOR STIMULATING STEM CELL PROLIFERATION AND MIGRATION

a technology of stem cell proliferation and migration, which is applied in the direction of drug compositions, immunological disorders, metabolism disorders, etc., can solve the problems of life-threatening hemorrhage in patients already immuno-compromised, breakdown of gi barrier function and septic condition, and reduce the tolerated dose, so as to stimulate hematopoiesis

Inactive Publication Date: 2009-03-12
TWARDZIK DANIEL R +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]The present invention is based upon two basic discoveries that have not been reported before in the literature of TGFα. Firstly, a novel genus of small peptides, much smaller than (50 amino acid human) TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic (therapeutic) agents for the same indications as full-length TGFα polypeptide (50 or 57 amino acids). Secondly, TGFα and the genus of smaller peptide fragments disclosed herein, were found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.

Problems solved by technology

This “side effect” reduces the tolerated dose of such drugs as it can cause a breakdown of the GI barrier function and septic condition in a patient already immuno-compromised.
This can also lead to life-threatening hemorrhage.

Method used

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  • LOOP PEPTIDE AND TGF alpha FOR STIMULATING STEM CELL PROLIFERATION AND MIGRATION
  • LOOP PEPTIDE AND TGF alpha FOR STIMULATING STEM CELL PROLIFERATION AND MIGRATION
  • LOOP PEPTIDE AND TGF alpha FOR STIMULATING STEM CELL PROLIFERATION AND MIGRATION

Examples

Experimental program
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Embodiment Construction

Loop Peptide

[0032]Human TGFα is a polypeptide of 50 amino acids and the corresponding rat sequence is shown in FIG. 1. The human or rat TGFα polypeptide can be divided roughly into three loop regions corresponding roughly (starting at the N terminus) to amino acids 1-21, to amino acids 16-32, and to amino acids 33-50. Each of the three foregoing loop regions in human TGFα was investigated for TGFα-like biological activity, such as stimulation of cellular proliferation as measured by 3H thyridine incorporation of stem cells. As shown in FIG. 2, only the Loop C peptide (corresponding to amino acids 33-50) showed significant TGFα biological activity and is therefore a TGFα mimetic peptide. Therefore, in view of the fact that the loop peptide exhibited TGFα biological activity, data obtained with TGFα (50 amino acid polypeptide or even the altered splice 57 amino acid polypeptide) is predictive. Accordingly, data from TGFα or TGFα 57 show what can be called “TGFα activity” and these are...

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Abstract

There is disclosed a novel genus of small peptides, smaller than human TGFα, identified as having TGFα biological activity and therefore being useful as pharmacologic agents. It is further disclosed that both TGFα and the genus of small peptides disclosed herein have therapeutic activity to stimulate hematopoiesis, e.g., in patients undergoing cytotoxic cancer chemotherapy, and also act as cytoprotective agents to protect patients undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis, and otherwise to support the barrier function of the GI tract, such as when it is harmed by cytotoxic therapy.

Description

TECHNICAL FIELD OF THE INVENTION[0001]The present invention provides a novel peptide that is derived from a loop or “lollipop” region of transforming growth factor alpha (TGF-α) and is biologically active for causing stem cells to proliferate and migrate. The present invention further provides a method for augmenting hematopoiesis, particularly trilineage hematopoiesis, and a method for suppressing immune functioning associated with autoimmune diseases, and a method for suppressing inflammatory responses mediated (in part) by excessive histamine release, comprising administering an effective amount of a TGF-α a polypeptide or a fragment thereof, such as the lollipop region. The present invention further provides a method for treating or preventing mucositis and gastrointestinal side effects in patients undergoing cancer treatment, comprising administering an effective amount of a TGF-α polypeptide or a fragment thereof, such as the lollipop region.BACKGROUND OF THE INVENTION[0002]Th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/10A61P1/00A61P29/00A61K38/22A61P25/00C07K7/08A61K48/00A61K31/17A61K31/196A61K31/337A61K31/513A61K31/519A61K31/704A61K31/7048A61K31/7068A61K31/7088A61K33/24A61K35/76A61K38/00A61P1/02A61P1/04A61P1/14A61P3/10A61P7/00A61P9/10A61P19/00A61P21/00A61P25/14A61P25/16A61P25/18A61P25/28A61P25/32A61P27/02A61P27/06A61P31/04A61P31/12A61P31/18A61P31/22A61P35/00A61P37/00A61P39/02A61P43/00C07K14/495
CPCA61K38/00C07K14/495A61K48/00A61P1/00A61P1/02A61P1/04A61P1/14A61P19/00A61P21/00A61P25/00A61P25/14A61P25/16A61P25/18A61P25/28A61P25/32A61P27/02A61P27/06A61P29/00A61P31/04A61P31/12A61P31/18A61P31/22A61P35/00A61P37/00A61P39/02A61P43/00A61P7/00A61P9/10A61P3/10Y02A50/30
Inventor TWARDZIK, DANIEL R.PASKELL, STEFANFELKER, THOMAS S.
Owner TWARDZIK DANIEL R
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