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Antibactrial wound suturing-free tissue adhesive

A tissue glue, wound technology, applied in the field of medical and health materials, can solve the problem of not being able to inhibit the activity of microorganisms

Inactive Publication Date: 2006-10-25
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

but does not inhibit microbial activity during wound healing

Method used

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  • Antibactrial wound suturing-free tissue adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The components and contents of the antibacterial wound seam-free tissue glue of the present invention are as follows:

[0038] Alpha-amyl cyanoacrylate 10

[0039] Decyl alpha-cyanoacrylate 20

[0040] Polybutylmethacrylate 0.5

[0041] Dibutyl phthalate 1.0

[0042] Chlorhexidine Iodine 0.1

[0043] The preparation method of the antibacterial wound seam-free tissue glue of the present invention is obtained by uniformly mixing the above components according to their contents.

Embodiment 2

[0045] The components and contents of the antibacterial wound suture-free tissue glue of the present invention are as follows:

[0046] α-Ethyl cyanoacrylate 40

[0047] Polyethylmethacrylate 2

[0048] Polyoctyl methacrylate 0.5

[0049] Diethyl phthalate 1.0

[0050] Dibutyl phthalate 1.0

[0051] erythromycin ethylsuccinate 0.5

[0052] Acetylspiramycin 0.5

[0053]The preparation method of the antibacterial wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above components according to their contents.

Embodiment 3

[0055] The components and contents of the antibacterial wound suture-free tissue glue of the present invention are as follows:

[0056] α-Ethyl cyanoacrylate 20

[0057] α-Propyl cyanoacrylate 20

[0058] α-Butyl cyanoacrylate 20

[0059] n-octyl alpha-cyanoacrylate 20

[0060] PMMA 2.5

[0061] Polyethylmethacrylate 2.5

[0062] Polyvinyl acetate 2.5

[0063] Diethyl phthalate 1.5

[0064] Dibutyl phthalate 2.5

[0065] Di-n-octyl phthalate 1

[0066] Dipropyl sebacate 1.5

[0067] Tobramycin 6

[0068] Erythromycin 6

[0069] The preparation method of the antibacterial wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above components according to their contents.

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Abstract

The present invention relates to an anti-bacterial wound non-suturing tissue glue. In the concrete, it relates to an alkyl alpha-cyanoacrylate tissue glue containing anti-bacterial agent. Its composition contains 30.0-80.0 portions of alkyl alpha-cyanoacrylate, 0.5-7.5 portions of strength improving agent, 1.0-8.5 portions of plasticity improving agent and 0.5-25.0 portions of anti-bacterial agent. The anti-bacterial agent is one or more than two kinds of cefmetazole, erythromycin ethylsuccinate, acetylspiramycin and chlorhexidine iodine.

Description

technical field [0001] The invention belongs to the field of medical and sanitary materials, in particular to α-cyanoacrylate alkyl ester wound-free tissue glue containing antibacterial components. Background technique [0002] Surgical and traumatic wounds can generally be closed using three methods: sutures, staples, and tissue glue. [0003] Tissue glue bonding method, that is, α-alkyl cyanoacrylate tissue glue closing wound method, has unique characteristics of bonding wounds. α-Alkyl cyanoacrylate tissue glue has been widely used as a seam-free tissue glue to close surgical wounds and traumatic wounds all over the world, especially for wounds that are difficult to close satisfactorily with suture, which saves time and energy, and can Adhesive tissue that is difficult to suture can provide a relatively sealed wound closure environment, no need to change dressings after surgery, has the effect of hemostasis, the wound is more beautiful after healing, and it is indispensa...

Claims

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Application Information

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IPC IPC(8): A61L17/10
Inventor 樊粤光孙鸿涛阮传良王海彬
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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