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Drug solution filling plastic ampoule and production method therefor

A manufacturing method and technology of liquid medicine, applied in the direction of medical containers, pharmaceutical packaging, packaged food, etc., can solve the problems of complicated manufacturing steps and rising manufacturing costs, and achieve the prevention of water vapor penetration, drug penetration, and drug absorption The effect of adsorption capacity

Active Publication Date: 2006-05-24
OTSUKA PHARM FAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these methods, it is necessary to separately use the material for containing the bag and the surface, so the manufacturing steps become complicated, and there are problems such as an increase in the manufacturing cost.

Method used

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  • Drug solution filling plastic ampoule and production method therefor
  • Drug solution filling plastic ampoule and production method therefor
  • Drug solution filling plastic ampoule and production method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Using a blow-fill-seal machine with a 2-layer blow mold, the inner layer was prepared from COP1 (polycycloolefin), the outer layer was prepared from PE1 (polyolefin), and 10 mL of 0.005% aqueous solution of nitroglycerin was filled inside to produce A plastic ampoule (inner volume 10mL) with a 2-layer structure for filling liquid medicine. The ampoules of 10 have figure 1 In the shape shown, the wall thickness of the tube is 100 μm in the inner layer and 700 μm in the outer layer.

Embodiment 2

[0134] Using a blow-fill-seal machine with a 2-layer blow mould, the inner layer is prepared from a plastic blend of COP1 (polycycloolefin) and PE1 (polyolefin) in the ratio ) to prepare an outer layer, and fill the inside with 20 mL of 0.005% nitroglycerin aqueous solution to manufacture a plastic ampoule (inner volume: 20 mL) having a two-layer structure for filling the drug solution. The ampoules of 10 have figure 1 In the shape shown, the wall thickness of the tube is 100 μm in the inner layer and 700 μm in the outer layer.

Embodiment 3

[0136] Using a blow-fill-seal machine with 3-layer blow molding, the inner layer is made of PE1 (polyolefin), the middle layer is made of COP1 (polycycloolefin), the outer layer is made of PE1, and it is filled with 0.005% nitro Glycerin aqueous solution 10mL, and a plastic ampoule (inner volume: 10mL) with a 3-layer structure was manufactured. The ampoules of 10 have figure 1 For the shape shown, the tube wall thickness is 50 μm for the inner layer, 100 μm for the middle layer, and 700 μm for the outer layer.

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Abstract

The invention provides a plastic ampoule filled with medicinal liquid, which has the functions of blocking gas, water vapor and light and preventing drug penetration, absorption and adsorption, and a preparation method thereof. The plastic ampoule 10 for filling medicinal solution of the present invention comprises a container main body 11, a fused portion 13 closing its opening 12 and a holding portion 14 connected thereto for twisting. The ampoule 10 is formed using a parison having two or more layers, at least one of which is a material selected from the group consisting of gas transmission, water vapor transmission, light transmission, drug transmission and A functional layer that prevents at least one of drug absorption and adsorption properties. That is, the parison is extruded from a multi-layer blow mold, clamped by the lower parting die to form the main body part 11 of the container, and after filling the liquid medicine 15 therein, the opening part 12 is clamped by the upper parting die to form a fusion joint. Part 13 and holding part 14, thereby making the product of the present invention.

Description

technical field [0001] The present invention relates to a plastic ampoule filled with liquid medicine in advance. In more detail, it relates to a device that can prevent water vapor, gases other than water vapor, light or medicines (pharmaceuticals, liquid medicines, their solvents, etc.) Disclosed is a plastic ampoule filled with a liquid medicine that absorbs and adsorbs medicines, liquid medicines, solvents, etc. contained therein to the inner surface of the ampoule, and a manufacturing method thereof. Background technique [0002] At present, most of the ampoules containing liquid medicine are made of glass. However, glass ampoules can cause the problem of dissolution of alkaline flakes when the pH of the liquid medicine contained in them is high. In addition, there are problems that fingers are easily cut when opening the ampoule, and there is a risk of the ampoule being broken, and a risk of fragments generated during opening being mixed into the liquid medicine, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/05
Inventor 长尾胜美冈本英志泉雅满河上启一井上富士夫
Owner OTSUKA PHARM FAB INC
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