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Mingmu-Dihuang preparation and new preparing method

A technology of preparation, Rehmannia glutinosa, applied in the field of Mingmu rehmannia glutinosa preparation and new preparation, can solve the problems of large dose, affecting clinical application, and many impurities

Inactive Publication Date: 2006-05-24
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in practice, because the medicine is prepared by powdering the medicinal materials into the medicine, there are many impurities and large doses, which seriously affect its clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The preparation method of dropping pill of the present invention:

[0067] prescription:

[0068] Rehmannia glutinosa 115g Cornus officinalis (made) 58g Moutan bark 43g Chinese yam 58g

[0069] Poria cocos 43g Alisma 43g Lycium barbarum 43g Chrysanthemum 43g

[0070] Angelica 43g Paeoniae Alba 43g Tribulus terrestris 43g Cassia cassia (calcined) 58g

[0071] PEG4000 100g

[0072] Makes 1000 pills

[0073] Preparation:

[0074] (1) Take Angelica and Tribulus terrestris, use supercritical extraction method (or steam distillation method): put it into a supercritical extraction tank, under the conditions of pressure of 20MPa, temperature of 40°C, and flow rate of 20L / h Extraction for 3.0h; analysis at a pressure of 5.5MPa, a temperature of 34.5°C (separation I), and 34.8°C (separation II) to obtain the extract; β-CD inclusion, the best process is: the ratio of β-CD to water is 1:8, the ratio of oil to β-CD is 1:6, sonicated for 30min to obtain clathrate;

[0075] (2)...

Embodiment 2

[0078] The preparation method of soft capsule of the present invention:

[0079] prescription:

[0080] Rehmannia glutinosa 400g Cornus officinalis (made) 200g Moutan bark 150g Chinese yam 200g

[0081] Poria cocos 150g Alisma 150g Lycium barbarum 150g Chrysanthemum 150g

[0082] Angelica 150g Paeoniae Alba 150g Tribulus terrestris 150g Cassia chinensis (calcined) 200g

[0083] PEG400 350g

[0084] Makes 1000 capsules

[0085] Preparation:

[0086] (1) Take Angelica and Tribulus terrestris, use supercritical extraction method (or steam distillation method): put it into a supercritical extraction tank, under the conditions of pressure of 20MPa, temperature of 40°C, and flow rate of 20L / h Extraction for 3.0h; analysis at a pressure of 5.5MPa, a temperature of 34.5°C (separation I), and 34.8°C (separation II) to obtain the extract; β-CD inclusion, the best process is: the ratio of β-CD to water is 1:8, the ratio of oil to β-CD is 1:6, sonicated for 30min to obtain clathrate...

Embodiment 3

[0090] The preparation method of granule of the present invention:

[0091] prescription:

[0092] Rehmannia glutinosa 400g Cornus officinalis (made) 200g Moutan bark 150g Chinese yam 200g

[0093] Poria cocos 150g Alisma 150g Lycium barbarum 150g Chrysanthemum 150g

[0094] Angelica 150g Paeoniae Alba 150g Tribulus terrestris 150g Cassia chinensis (calcined) 200g

[0095] Made into 1000g

[0096] Preparation:

[0097] (1) taking angelica, tribulus terrestris, and cassia herba into powder;

[0098] (2) Take the remaining medicinal materials of the prescription, soak them with 65% ethanol for 40 minutes, then heat and reflux for extraction three times, each time for 1 hour, combine the extracts, concentrate under reduced pressure to form a thick ointment, and set aside;

[0099] (3) Combine the above active ingredients, add 5.0 g of aspartame and 230.0 g of dextrin, granulate, dry, and spray 5.0 g of essence to obtain 1000 g of granules.

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Abstract

The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of deficiency of liver-yin and kidney-yin, dry eyes and photophobia, poor vision, blurring of vision and epiphora induced by wind etc, and its preparation process. It can be made into dripping pills and soft capsule preparation.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition and a preparation process thereof, in particular to a prescription and a preparation process thereof for liver and kidney yin deficiency, astringent eyes, photophobia, blurred vision, and tears flowing against the wind. Background technique: [0002] Deficiency of liver and kidney yin, astringent eyes, photophobia, blurred vision, and weeping in the wind are common clinical symptoms. Traditional Chinese medicine often treats them by nourishing the kidney, nourishing the liver, and improving eyesight. The curative effect is remarkable. Mingmu Dihuang Pill is its representative drug . However, in practice, because the medicine is prepared by powdering the medicinal materials, it leads to many impurities and large doses, which seriously affects its clinical application. [0003] Compared with ordinary pills, the preparation prepared by the extraction process of the present invention can...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/16A61K9/20A61K9/48A61P1/14A61P27/02
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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