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Peroxisome propogation agent activating receptor gamma ligand excitomotor and its use

A technology of peroxisomes and proliferators, applied in the medical field

Inactive Publication Date: 2006-01-04
RENJI HOSPITAL ATTACHED TO SHANGHAI NO 2 MEDICALUNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, although the medicinal value of resveratrol has been known in the prior art, its exact mechanism

Method used

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  • Peroxisome propogation agent activating receptor gamma ligand excitomotor and its use
  • Peroxisome propogation agent activating receptor gamma ligand excitomotor and its use
  • Peroxisome propogation agent activating receptor gamma ligand excitomotor and its use

Examples

Experimental program
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Embodiment 1

[0018] Example 1 Establishment and Screening of PPARγ Ligand Agonist Screening Model

[0019] 1. Materials and Cell Lines

[0020] Materials: DMSO (dimethyl sulfoxide) was purchased from SIGMA; pioglitazone and resveratrol were purchased from Merk; penicillin, streptomycin, RPMI 1640 medium and fetal bovine serum were purchased from PAA laboratories GmBH in Australia; 4 mm The electroporation cup was purchased from BIO-RAD Company; the human PPARγ full-length expression vector PSG5-hPPARγ and the PPARγ reporter vector pACO-TKpGL3 were kindly provided by Dr. Celine Haby of the Pasteur Institute in France, and the internal reference vector was pSV-β- Galactosidase Control Vector. The luciferase Assay System kit from Promega Company and the Lumat LB9507 Fluorescence Quantitative Instrument from Cberthold Technologies Company were used for fluorescence measurement; the β-Galactosidase EnzymeAssay System kit from Promega Company was used to measure β-gal activity; the Gene PulserX...

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Abstract

The present invention discloses resveratrol as a kind of peroxisome propagation agent activating receptor gamma ligand excitomotor. The present invention also discloses the application of resveratrol as peroxisome propagation agent activating receptor gamma ligand excitomotor. The present invention also discloses one kind of medicine composition containing resveratrol as peroxisome propagation agent activating receptor gamma ligand excitomotor in the effective amount and pharmaceutically acceptable carrier or excipient.

Description

technical field [0001] The invention belongs to the field of medicine and relates to an agonist, in particular to a peroxisome proliferator-activated receptor gamma ligand agonist and application thereof. Background technique [0002] Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear transcription factors that have attracted much attention in recent years, and are divided into three subtypes: α, β and γ. A series of experimental results not only established the key role of PPAR α and γ in maintaining the balance of lipid and glucose metabolism in the body, but also ligand agonists of PPAR α—fibrate lipid-lowering drugs and ligand agonists of PPAR γ— —TZD insulin sensitizers (pioglitazone, troglitazone, etc.) have been used clinically as lipid-lowering drugs and antidiabetic drugs, respectively. In addition, recent studies have also suggested that such nuclear transcription factors, especially PPARγ, can play an anti-inflammatory role in atherosclero...

Claims

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Application Information

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IPC IPC(8): C07C39/21A61K31/05A61P9/10
Inventor 王长谦葛恒王彬尧
Owner RENJI HOSPITAL ATTACHED TO SHANGHAI NO 2 MEDICALUNIV
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