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Milrinone sodium chloride injection and production thereof

A technology of agricultural sodium chloride and injection, which is applied in the field of medicine, can solve problems such as inconvenient use, and achieve the effects of convenient clinical use, good patient tolerance, and simple preparation process

Active Publication Date: 2005-10-12
LUNAN BETTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The specifications of milrinone injection currently on the market are 5ml: 5mg, 10ml: 10mg, 20ml: 20mg, but they all need to be diluted with normal saline or glucose before injection, which is very inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Milrinone 15g

[0025] Sodium chloride 830g

[0026] Lactic acid (85%) 31g

[0027] Appropriate amount of water for injection

[0028] Preparation process: Dissolve sodium chloride in an appropriate amount of water for injection, add 0.1% activated carbon, heat and boil for 10 minutes, filter; take another appropriate amount of water for injection, add milrinone and lactic acid, stir to dissolve milrinone, and then add to the filtered Add water for injection to the full amount in the sodium chloride solution, adjust the pH value to 3.2-4.0 with lactic acid or sodium hydroxide, and finally fill and sterilize it to make 1000 bottles.

Embodiment 2

[0030] Milrinone 22g

[0031] Sodium chloride 858g

[0032] Lactic acid (85%) 34g

[0033] Appropriate amount of water for injection

[0034] The preparation process is the same as in Example 1.

Embodiment 3

[0036] Milrinone 24g

[0037] Sodium chloride 862g

[0038] Lactic acid (85%) 35g

[0039] Appropriate amount of water for injection

[0040] The preparation process is the same as in Example 1.

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PUM

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Abstract

A milrinone-sodium chloride injection for treating congestive heart failure is proportionally prepared from milrinone, sodium chloride and lactic acid.

Description

technical field [0001] The invention relates to an injection, in particular to a milrinone sodium chloride injection for treating congestive heart failure and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Heart failure, also known as congestive heart failure, refers to a syndrome in which the blood output is reduced due to primary heart damage and cannot meet the needs of tissue metabolism under the condition of normal venous return. Clinically, pulmonary circulation and / or Systemic circulation congestion and tissue hypoperfusion are the main features. According to the statistics of the World Health Organization, the incidence rate of chronic heart failure in the population is 1.5-5.6%, and it reaches 7.4% over the age of 65; the mortality rate of patients with heart failure within two years after diagnosis is 37%, and the mortality rate after 5 years is 82%. . With the aging of society, the incidence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/444A61P9/04
Inventor 赵志全
Owner LUNAN BETTER PHARMA
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