Hypericum sampsonii hance total extract, and its preparing method and use

An extract, the technology of Yuanbaocao, applied in the field of medicine, can solve the problems such as the preparation method and application of the total extract of Yuanbaocao that have not yet been seen

Inactive Publication Date: 2005-07-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0026] The above-mentioned documents have reported the chemical structure of ketones, but so far, there have been no reports on the total extract of C. involucrata and its preparation method and use, nor have the raw materials of the total extract of C. involucrata been used for the preparation of antidepressant drugs Aspects of reports

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  • Hypericum sampsonii hance total extract, and its preparing method and use
  • Hypericum sampsonii hance total extract, and its preparing method and use
  • Hypericum sampsonii hance total extract, and its preparing method and use

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preparation example Construction

[0076] (1) The preparation method of Yuanbaocao total extract

[0077] The said total extract of Herba Indigo in the present invention is extracted from Herba Indigo, raw material used is Herba Indigo L., and the preparation method of Herb Indigo total extract comprises the following steps:

[0078] ①Take some Yuanbaocao, add solvent and mix to obtain the extract;

[0079] ② Filtrate and concentrate the extract to obtain the total extract of Yuanbaocao.

[0080] Taking hydrated ethanol (1%-99% ethanol) as the solvent as an example, the specific steps for preparing the total extract of Yuanbaocao are described below. There are two basic methods for the specific operation of the preparation, as follows:

[0081] Method ①: Take the whole herb or the aboveground part of the whole herb, remove the weeds and soil, dry it in an oven with the temperature controlled below 65°C, cut it into small pieces after drying, crush it with a grinder, and pass it through a 30-mesh coarse sieve ...

Embodiment 1

[0139] Embodiment 1, the preparation of the total extract of Yuanbaocao

[0140] Take 50kg of the whole herb of Yuanbaocao, remove weeds and soil, dry in an oven, the temperature is controlled below 65°C, cut into small sections after drying, pulverize with a pulverizer, pass through a 30-mesh coarse sieve, and add hydrated ethanol (60% ethanol) Percolation, and continuously add hydration ethanol for extraction until the color of the extract is very light or colorless, filter the extract with gauze, concentrate the filtrate under reduced pressure at 55°C to a relative specific gravity of 1.02-1.05, and then dry it in a vacuum (vacuum degree 760mmHg , and the temperature is maintained between 55° C. and 65° C.) to obtain 6.50 kg of a tan dry powder of the total extract. The yield of Yuanbaocao total extract is 13.0%. In this total extract, the total content of naphthalene bianthrone compounds is 0.08%, the total content of flavonoids is 8.80%, and the total content of Yuanbaoca...

Embodiment 2

[0141] Embodiment 2, the preparation of the total extract of Yuanbaocao

[0142] Get 50kg of the above-ground part of the whole herb of Yuanbaocao, remove weeds and soil, dry in an oven, and the temperature is controlled below 65°C. After drying, cut the medicinal material into small sections no more than 5cm, add 20 times of hydrated ethanol (70% ethanol), Reflux extraction was carried out at 95°C, the extract was filtered under reduced pressure, concentrated under reduced pressure at 55°C, and then spray-dried (inlet air temperature 120°C, outlet air temperature 80°C, storage tank temperature 90°C) to obtain the total The tan dry powder of the extract is 8.25kg. The yield of the total extract of Yuanbaocao is 16.5%. In the total extract, the total content of naphthalenedic anthrone compounds is 0.06%, the total content of flavonoids is 11.90%, and the total content of Yuanbaocao ketones is 4.30%. %.

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Abstract

The main effective components in the total extractive of Sampson St. John swort herb include naphthodianthrones, flavones and Sampson St. John swort herb ketone. The preparation process of the total extractive of Sampson St. John swort herb includes mixing Sampson St. John swort herb with solvent to obtain extracted liquid, filtering the extracted liquid and concentration. The process is simple, safe and low in cost. Experiment shows that the total extractive of Sampson St. John swort herb may be used in preparing medicine for treating depression and is safe, efficient, stable and cheap in preventing and treating depression.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to extracts of natural medicines and their preparation methods and uses, more specifically to the total extract of Amaranthus indica and its preparation method and the application of the total extract and raw materials in the preparation of medicines . Background technique [0002] Affective mental disorder, one of the five major diseases that endanger human health in the world today, has brought a heavy burden to human society. Depression in affective disorders is a group of diseases characterized by significant and persistent depression, behavioral rigidity and pessimistic world-weariness. It's so common, in fact, that it's been called the "common cold" of mental illness, and it's also a serious, life-threatening illness that afflicts tens of millions of people around the world. Therefore, there is an urgent need for safe, efficient and inexpensive antidepressants. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B63/00C07C45/78C07C49/727C07C403/24C07D311/30C07H1/08C07H17/07
Inventor 张巧艳郑清明秦路平郑汉臣黄宝康
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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