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Zinc-containing medicinal complex and method for making same

A compound, the technology of zinc acetate, applied in sugar derivatives, antibacterial drugs, organic chemistry, etc., can solve the problems of lack of convincing characterization results and single characterization means, and achieve the effect of complete reaction process and high product purity

Inactive Publication Date: 2005-07-06
KUNMING INST OF PRECIOUS METALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the article "Synthesis and Characterization of Baicalin-Zinc Complexes" published in the 2nd issue of "Journal of Nanjing Railway Medical College" in 1988, it was reported that zinc ions (Zn 2+ ) and baicalin, and its structure was characterized, but its characterization method is relatively simple, making its characterization results unconvincing

Method used

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  • Zinc-containing medicinal complex and method for making same
  • Zinc-containing medicinal complex and method for making same
  • Zinc-containing medicinal complex and method for making same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] ① Dissolve baicalin with ethanol, the volume ratio of baicalin to ethanol in the solution is baicalin:ethanol volume ratio=1:8,

[0027] ②Slowly add the zinc acetate ZnAC aqueous solution to the mixed solution obtained in step ①, the molar ratio of baicalin to zinc acetate ZnAC in the mixed solution is baicalin: zinc acetate ZnAC=1:1.6,

[0028] ③Adjust the pH value of the mixed solution obtained in step ② with sodium hydroxide and NaOH aqueous solution to a pH of 7.5, and then reflux for 3 hours in a water bath at 70°C, wash and dry for many times to obtain the target compound zinc baicalin.

Embodiment 2

[0030] ① Dissolve baicalin with ethanol, the volume ratio of baicalin to ethanol in the solution is baicalin: ethanol volume ratio = 1:12,

[0031] ②Slowly add zinc acetate ZnAC aqueous solution to the mixed solution obtained in step ①, the molar ratio of baicalin to zinc acetate ZnAC in the mixed solution is baicalin: zinc acetate ZnAC=1: 1.6, adjust the mixture obtained in step ② with sodium hydroxide and NaOH aqueous solution The pH of the solution is 7, and then it is refluxed for 4 hours at 75°C in a water bath, washed and dried to obtain the target compound zinc baicalin.

Embodiment 3

[0033] ① Dissolve baicalin with ethanol, and control the volume ratio of baicalin to ethanol in the solution to the volume ratio of baicalin: ethanol = 1:10,

[0034] ②Slowly add the zinc acetate ZnAC aqueous solution to the mixed solution obtained in step ①, and the molar ratio of baicalin to zinc acetate ZnAC in the mixed solution is controlled to be baicalin: zinc acetate ZnAC=1:1.6,

[0035] ③Adjust the pH value of the mixed solution obtained in step ② with sodium hydroxide and NaOH aqueous solution to 8, and then reflux for 6 hours in a water bath at 80°C, wash and dry for many times to obtain the target compound zinc baicalin.

[0036] Example number

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Abstract

The invention relates to a medicinal baicalin zinc complex and a preparation method thereof. In the preparation method, baicalin is dissolved by ethanol, zinc acetate and sodium hydroxide aqueous solutions are added, the pH value of the mixed solution is regulated to 7~8, and after reflux of 3~6 hours under water bath of 70í½80íµ, scrubbing and drying, the objective compound is obtained. The baicalin zinc ZnBA has a remarkable inhibitory action to staphylococcus aureus and clostridium. The preparation method is simple and easy, and the product has a high purity.

Description

Technical field [0001] The invention relates to a zinc complex with anti-inflammatory, antibacterial and other pharmaceutical uses and a preparation method thereof. The baicalin zinc complex of the present invention has significant bacteriostatic effects on Staphylococcus aureus, Clostridium sporogenes, Candida albicans, and Agrobacterium. Background technique [0002] The traditional Chinese medicine Scutellaria baicalensis Georgi, English name scutellaria baicalensis georgi, tastes bitter and cold, has the effects of clearing away heat and moisturizing dryness, reducing fire and detoxification. Its active ingredients are mainly baicalin, baicalein, and a small amount of wogonin. They are all flavonoids. At present, there are many varieties of compound preparations and single-flavor preparations containing Scutellaria baicalensis Georgi. They are mainly used as antibacterial and anti-inflammatory drugs. Baicalin, structural formula such as figure 2 As the main active ingredient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P31/04C07H17/06
Inventor 王玉天普绍平高传柱高文桂刘祝东余尧刘洋
Owner KUNMING INST OF PRECIOUS METALS
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