Urapidil powder and injection preparation and preparing method

A technology of urapidil and powder injection, applied in the field of medicine, can solve problems such as patients' reluctance to use, barriers to expanding use, and freezing of water injections, and achieve long storage period, convenient transportation, and good stability

Inactive Publication Date: 2005-06-15
GUANGDONG QIFANG MEDICINES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, we have approved the marketing of urapidil injection, but with the continuous expansion of production, quality problems also appear from time to time, and the water injection freezes in winter in the north, which is inconvenient to use, pain in intramuscular injection, and patients are unwilling to use it. Barriers to expanded use

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0008] The preparation process of the present invention is further illustrated below by specific examples, but not limited to the following examples:

[0009] 1. Use urapidil or uradil hydrochloride as raw material in the workshop below 100 grades, add appropriate amount of water, adjust the pH to 4.5-8.5, the solution is sterile filtered, sterile spray dried, sealed to get the required powder injection The raw materials are divided into bottles containing 25 mg of uradil, capped and packaged to obtain the finished product.

[0010] 2. Use urapidil or uradil hydrochloride as raw materials in the workshop below 100 grades, add appropriate amount of water and auxiliary materials, adjust the pH to 4.5-8.5, pass the solution through aseptic filtration, aseptic spray drying, and seal it to get what you need The powder injection raw material is divided into bottles containing 25 mg of urapidil, capped and packaged to obtain the finished product.

[0011] 3. Precipitate uradil or ur...

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PUM

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Abstract

A powder injection of urqpidil is prepared from urqpidil or its physiologically acceptable salt, and the pharmacologically acceptable auxiliary for injection. Its advantage is high stability and quality.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine in a special dosage form for cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Urapidil is a selective α1-receptor blocker with dual peripheral and central hypotensive effects. Peripheral dilation of blood vessels is mainly through blocking post-synaptic α1 receptors, so that the peripheral resistance is significantly reduced and blood vessels are dilated. The central effect is to reduce blood pressure by activating 5-hydroxytryptamine-1A receptors and reducing the sympathetic feedback of the medullary cardiovascular regulation center. This product has the effect of blocking post-synaptic α1 receptors and blocking peripheral α2 receptors, but the former is the main one. The relaxation effect of this product on venous blood vessels is greater than that on arterial blood vessels, and can reduce renal vascular res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/506A61P9/12
Inventor 刘军杨春玮孔庆文
Owner GUANGDONG QIFANG MEDICINES CO LTD
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