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Continuous ion exchage extracting process for L-phenylalanine

A continuous ion and phenylalanine technology is applied in the field of continuous ion exchange extraction process of L-phenylalanine, which can solve the problems of low extraction yield and product purity, low utilization rate of upper column resin and high product extraction cost. , to achieve the effect of reducing extraction cost, realizing clean process production and saving acid and alkali consumption

Inactive Publication Date: 2005-05-18
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

A large amount of salt and waste water are produced in the metal salt precipitation method, and its extraction yield and product purity are low; in the membrane separation technology method, due to the high price of membrane equipment and the high maintenance cost of the membrane, the extraction cost of the product is too high High; in the interstitial ion exchange method, the concentration in the upper column solution is low (3-5g / L), the utilization rate of the upper column resin is low (generally 60-70%), the eluent consumption is large, and the activation of the resin , Regeneration and cleaning need to consume a lot of acid and alkali, resulting in high extraction costs

Method used

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  • Continuous ion exchage extracting process for L-phenylalanine

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Effect test

Embodiment 1

[0031] Take 10m 3 The upper column liquid, the concentration of L-phenylalanine is 20 g / L, with 2m 3 / h feed rate into the continuous chromatographic system, the adsorption pH is controlled at 2.0, and then 0.3mol / l eluent at 2m 3 The flow rate of / h washes off the phenylalanine adsorbed on the resin, and then obtains 197.6 kilograms of L-phenylalanine crystals after concentrating, crystallizing and drying the obtained L-phenylalanine eluent, and the purity is 98.8%, the yield is 98.5%.

Embodiment 2

[0033] Take 10m 3 The upper column liquid, the concentration of L-phenylalanine is 20 g / L, with 3m 3 / h feed rate into the continuous chromatographic system, the adsorption pH is controlled at 2.0, and then 0.3mol / l eluent at 2m 3 The flow rate of / h washes off the phenylalanine adsorbed on the resin, and then obtains 196.2 kilograms of L-phenylalanine crystals after concentrating, crystallizing and drying the obtained L-phenylalanine eluent, and the purity is 99.7%, the yield is 97.8%.

Embodiment 3

[0035] Take 10m 3 The upper column liquid, the concentration of L-phenylalanine is 20 g / L, with 4m 3 / h feed rate into the continuous chromatographic system, the adsorption pH is controlled at 2.0, and then 0.5mol / l eluent at 1m 3 The flow rate of / h washes off the phenylalanine adsorbed on the resin, and then obtains 195.6 kilograms of L-phenylalanine crystals after concentrating, crystallizing and drying the obtained L-phenylalanine eluent, and the purity is 98.4%, the yield is 97.2%.

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Abstract

The present invention relates to the continuous ion exchange extracting process of L-phenylalanine as medicine intermediate. Continuous ion exchange process is utilized in realizing the high efficiency extraction of L-phenylalanine; and includes centrifugal filtering to eliminate microbe cell and segment with the column liquid, continuous ion exchange system to adsorb L-phenylalanine, elution with eluent, and concentrating crystallization. The specific technological parameters includes feeding the material liquid into the continuous ion exchange system with 10-20 g / L column liquid in the speed of 1-5 cu m / hr, adsorption pH of 1-3, eluent amount of 2-4 cu m / hr, etc. The present invention has extraction yield over 97 %, product purity over 99 %, 30 % raised resin utilization, 80 % lowered acid and alkali consumption and 3-5 times raised unit resin extraction capacity.

Description

technical field [0001] The invention relates to a continuous ion-exchange extraction process for L-phenylalanine, a pharmaceutical intermediate, that is, the high-efficiency extraction of L-phenylalanine is realized by using the continuous ion-exchange separation process. Background technique [0002] L-phenylalanine is one of the eight essential amino acids for the human body. It is mainly used for: (1) as a raw material for the synthesis of food additives, such as the synthesis of the sweetener aspartame; (2) as a raw material for medicines, such as Amino acid infusion, comprehensive amino acid preparations, intermediates of certain amino acid anticancer drugs, and raw materials for the production of epinephrine, thyroxine and melanin. In recent years, since aspartame has become the most popular sweetener product in the international market and has been widely used in the food and beverage industries, it has become the biggest driving force for the surge in demand for L-ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/40C07C229/36
Inventor 万红贵韦萍于荣华周华何若平吴昊欧阳平凯
Owner NANJING UNIV OF TECH
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