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Absorbable medical chitin suture lines and their production

A manufacturing method, chitosan technology, applied in medical science, surgery, surgical instruments, etc., can solve the problems of low breaking strength of sutures, poor biocompatibility, complex production process, etc., to achieve improved flexibility, complete absorption, Ease of use

Inactive Publication Date: 2004-12-08
TIANJIN JIUKANG BIOLOGICAL ENG DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these materials have certain functions of being degradable and absorbable by tissue cells, there are still some deficiencies, such as low breaking strength of sutures, long absorption period, certain irritation, and biocompatibility. Poor, complex production process, or limited sources of materials, etc.

Method used

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Examples

Experimental program
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Embodiment Construction

[0023] (1) Select the appropriate chitosan, the deacetylation degree, viscosity, molecular weight, pH value, ash content and other indicators of chitosan are: deacetylation degree: 65%-95%, moisture: ≤ 10%, ash content: ≤ 1 %, viscosity: 80mPa.s-200mPa.s, total arsenic: ≤1.0mg / kg (as AS 2 o 2 (calculated), lead: ≤1.5mg / kg (calculated in pb), mercury: ≤0.3mg / Kg (calculated in Hg); the choice of chitosan should be determined according to the length of the suture absorption period, and generally the degree of deacetylation is high , the longer the absorption period, the higher the viscosity or molecular weight of chitosan, the greater the tensile strength of the thread. Dissolve it with 0.1%-2% acetic acid or hydrochloric acid to make the chitosan concentration 0.01%-2%, and then add a small amount of glycerin or vegetable oil as needed to improve the flexibility of the finished suture. Stir well and vacuum to remove air bubbles.

[0024] (2) Prepare a saturated solution of ch...

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PUM

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Abstract

An absorbable medical chitosan suture is prepared from chitosan and glycerine or vegetable oil through preparing coarse chitosan suture, preparing saturated high-concentration chitosan solution, twisting and coating film. Its advantage is high tension strength.

Description

1. Technical field [0001] The invention relates to a method for manufacturing medical sutures, in particular to a method for making absorbable medical sutures from pure natural polymer polysaccharide chitosan. 2. Technical background [0002] There are two main types of medical surgical sutures. One is non-absorbable sutures. The biggest disadvantage of this type of sutures is that they need to be removed after the operation, and there are often obvious scars at the stitches of the sutures. The other type is absorbable medical sutures, which do not need to be removed after surgery and have little or no scarring at the stitches. Therefore, many domestic and foreign research institutions are devoting themselves to research in this field. [0003] At present, there are some invention patents for absorbable medical sutures in China, such as patent publication number CN1195559A titled polyester absorbable medical sutures and its manufacturing method; CN85108766A titled amniotic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10
Inventor 张勇邓志强邓云强
Owner TIANJIN JIUKANG BIOLOGICAL ENG DEV
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