Method of identifying a plant extract

An extract and technology of ginkgo biloba, applied in the field of "identity of ginkgolide B", can solve the problems of not having EGB761 biological efficacy, EGB761 profit infringement, etc.

Inactive Publication Date: 2005-01-19
SOC DE CONSEILS DE RECH & DAPPLICATIONS SCI SAS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Get a fake EGB 761  Although the patients of the preparation believed it to be true, there is no EGB 761 in this counterfeit preparation  full biological efficacy of
Further, EGB 761  profits have been jeopardized

Method used

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  • Method of identifying a plant extract
  • Method of identifying a plant extract

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Embodiment Construction

[0074] The term "Ginkgo terpenoids" includes all natural terpenes and synthetic Ginkgo terpenoids from the gymnosperm plant Ginkgo biloba, their pharmaceutically active derivatives and salts, and mixtures thereof. Examples of ginkgo terpenoids include ginkgolides. Examples of ginkgo terpenoids are disclosed in the following documents: Ginkgolides, Chemistry, Biology, Pharmacology, and Clinical Perspectives, J.R. Provs. Science Publishers, Edited by P. Braguet (1988); F.V. DeFeudis, Ginkgo biloba extract (EGB 761 (g)) ; Pharmacological Activities and Clinical Applications, Elsevier, Chapter II (1991).

[0075] The term "ginkgolide" used in the present invention includes various ginkgolides disclosed in the above cited books and their non-toxic pharmaceutically active derivatives. Examples of ginkgolide derivatives include tetrahydro derivatives, acetyl derivatives, and alkyl esters, such as disclosed in Okabe, et al., J.Chem.Soc.(c), pp.2201-2206(1967) Monoacetate derivatives...

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Abstract

The present invention is directed to a method of establishing an identity of Ginkgo biloba leaves or isolated ginkgolide B (GKB) or another component of the extract of Ginkgo biloba leaves, by obtaining a gene regulation profile. The invention is also directed to a method of verifying the identity of a Ginkgo biloba extract by comparing the gene regulation profile of a Gingko biloba extract of unknown or questionable origin with the gene regulation pofile of a Gingko biloba extract of known origin. The present invention is further directed to a method of establishing a gene expression profile of Ginkgolide A, Ginkgolide B or any other component isolated from a Ginkgo biloba extract, more particularly, from EGB 7613.

Description

technical field [0001] The present invention relates to a method for establishing the "identity" of Ginkgo bilobaleaves or an extract component of Ginkgo biloba leaves, isolated ginkgolide B (GKB) (ginkgolide B), by obtaining a "gene regulatory profile" method. The present invention also relates to a method for determining the identity of Ginkgo biloba extracts by comparing the gene regulatory profiles derived from Ginkgo biloba extracts from unknown or questionable sources with those from known sources. verify. "Known source" means that the extract is of commercial origin. In a preferred aspect of the invention, the known source of Ginkgo biloba extract is EGB 761  , EGB 761  Manufactured and sold by IPSEN, Paris, France. More specifically, the present invention relates to an assay said to be EGB 761  Authenticity of extracts of unknown origin. The present invention further relates to a method for establishing the gene expression profile of Ginkgolide A, Ginkgolide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68C12Q1/6809C12N15/09C12Q1/6837
CPCC12Q1/6809C12Q1/6837C12Q1/68
Inventor 凯蒂·德里厄瓦斯里奥斯·帕帕左普洛斯
Owner SOC DE CONSEILS DE RECH & DAPPLICATIONS SCI SAS
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