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IgG epitope peptide of whey allergen beta-lactoglobulin

A technology of epitope peptides and allergens, which is applied in the field of immunology, can solve the problems of less reports on epitope localization of milk whey allergens

Pending Publication Date: 2022-08-09
AUSNUTRIA DAIRY CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for identification of beta lactic acid antigens from cow's milk by comparing them with those found on other species like humans or dogs (BSA). These differences can indicate an allergies caused due to different sources such as animal feedings or food ingredients used during production processes.

Problems solved by technology

This patented technical problem addressed in this patents relates to studying the relationship between different types of animal feedstuff ingredients like wheat germ meal flour, lamb stearbons, barley bean powder, oatmea albumina, alpha lactic aldehydes, tannoid compounds, chlorophyllanes, carboxymethyltrypsone soluble factor, histidase, tryptic enzymes, etc., while investigating various structural features related to these components.

Method used

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  • IgG epitope peptide of whey allergen beta-lactoglobulin
  • IgG epitope peptide of whey allergen beta-lactoglobulin
  • IgG epitope peptide of whey allergen beta-lactoglobulin

Examples

Experimental program
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Effect test

Embodiment 1

[0040] 1. Construction of serum pools for patients with milk allergy

[0041] 1. Indirect ELISA to screen serum of patients with milk allergy

[0042] Allergy patient serum used in this study was donated by Peking Union Medical College Hospital. The level of sIgG against cow's milk protein in the serum of allergic patients was detected by ImmunoCAP, and the serum of infants and young children with cow's milk protein sIgG level greater than or equal to 0.35kUA / L and aged 0-3 years was selected for ELISA. Determination of anti-β-lactoglobulin specific immunoglobulin G (BLG-sIgG) in serum of patients with cow's milk allergy by indirect ELISA. Study on the linear epitope of ovomucoid IgE by ELISA method [D]. Tianjin Medical University, 2020: 11-16.).

[0043] The coating solution is 0.05mol / L carbonate buffer with pH 9.6. The washing solution, blocking solution, serum, secondary antibody, etc. are all diluted with 0.01M PBS buffer. The washing solution contains 0.05% (v / v) Twee...

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Abstract

The invention relates to the technical field of immunology, in particular to IgG epitope peptide of whey allergen beta-lactoglobulin. The invention provides an IgG binding epitope of beta-lactoglobulin, and the epitope aims at the epitope of specific cow milk whey allergen of Chinese population, and has great significance on the molecular mechanism of cow milk allergy, the screening of protease for guiding directional breaking of the epitope and the development of low-allergy whey protein products based on the epitope.

Description

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Claims

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Application Information

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Owner AUSNUTRIA DAIRY CHINA
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