Application of pectin ECG composition in inhibition of formation of gastrointestinal pyridine derivatives

A technology of pyridine derivatives and pyridine derivatives in the gastrointestinal tract, which is applied in the pectin ECG composition and the application field of inhibiting the formation of pyridine derivatives in the gastrointestinal tract, can solve the problems of raw material discarding and low processing utilization rate, and achieve Wide application prospects, strong free radical scavenging ability, and significant anti-pyridine derivatives formation effect

Active Publication Date: 2022-07-08
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic pectin resources are abundant, but the processing utilization rate is low, and most of the raw materials are directly discarded. If they can be comprehensively utilized, it will bring huge economic effects

Method used

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  • Application of pectin ECG composition in inhibition of formation of gastrointestinal pyridine derivatives
  • Application of pectin ECG composition in inhibition of formation of gastrointestinal pyridine derivatives
  • Application of pectin ECG composition in inhibition of formation of gastrointestinal pyridine derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Screening of pyridine derivatives production inhibitors

[0021] (1) Add ECG, pectin, and pectin-ECG composition (pectin-ECG mass ratio 1:1) to 4 mL of artificial saliva (simulated salivary fluid, SSF, see Table 1 for preparation method) stock solution, and the final concentration is kept at 0.3g / L. Then add 25μL of 0.3mol / L CaCl 2 , Add ultrapure water to make up to 5mL. 200 mg of bovine serum albumin (BSA) and 11.36 μL of 8.8 mol / L glyoxal (GO) were added to establish a bovine serum albumin-glyoxal model. Mix well for 2 minutes and serve as the oral group. The control group contained no ECG, pectin, pectin ECG composition.

[0022] Table 1 Preparation of simulated digestive solution stock solution

[0023]

[0024]

[0025] (2) In step (1), 3.75 mL of artificial gastric fluid (SGF, preparation method is shown in Table 1) stock solution was added, and the pH value was adjusted to 2.0 with 0.1 mol / L HCl solution. Then add 0.25mL pepsin (80000U / mL)...

Embodiment 2

[0030] Example 2: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate

[0031] Methods as below:

[0032] (1) 0.2 mL of the intestinal digestion group sample solution diluted 2 times with water was mixed with 3.8 mL of a 0.1 mmol / L DPPH ethanol solution to form a sample group.

[0033] (2) 0.2 mL of the intestinal digestion group sample solution diluted 2 times with water was mixed with 3.8 mL of ethanol solution to serve as a control group.

[0034] (3) 0.2mL H 2 O was mixed with 3.8 mL of 0.1 mmol / L DPPH ethanol solution as blank group.

[0035] (4) 0.2mL H 2 O was mixed with 3.8 mL of ethanol solution for zero adjustment.

[0036] (5) The solutions of each group of steps (1), (2), (3) and (4) were put into the dark conditions to react for 30 min.

[0037] (6) Use a microplate reader to measure the absorbance of each group of reaction solutions at a wavelength of 517 nm. The data of the sample group, control group and blank group need to be subtracted and ...

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PUM

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Abstract

The invention discloses an application of a pectin ECG composition in inhibition of formation of gastrointestinal pyridine derivatives, and belongs to the field of health foods or medicines. The invention finds that the combined use of pectin and ECG can significantly improve the effect of inhibiting the formation of pyridine derivatives in gastrointestinal tracts, and the oxidation resistance of the combination of pectin and ECG is significantly stronger than that of single pectin or ECG. The pectin and the ECG or the composition containing the pectin and the ECG can be used for preparing health-care foods or medicines for inhibiting formation of the pyridine derivatives or resisting oxidation or treating, delaying or improving diseases related to the pyridine derivatives, and has wide application prospects in the fields of oxidation resistance, aging resistance, diabetes resistance and the like.

Description

technical field [0001] The invention belongs to the field of health food or medicine, and relates to the application of a pectin ECG composition in inhibiting the formation of pyridine derivatives in the gastrointestinal tract. Background technique [0002] Although the Maillard reaction that occurs during food processing can improve the flavor and quality of food, it also generates a large amount of harmful substances, which have certain toxicity and carcinogenicity. Pyridine derivatives are a kind of Maillard reaction products, which are cross-links between two lysine residues. It is closely related to various chronic diseases, and the accumulation in the body will cause various complications of diabetes. It can reduce the harm of Maillard reaction products to the human body by inhibiting the formation of pyridine derivatives, thereby delaying aging and reducing the risk of various chronic diseases such as diabetes. [0003] Pectin is a polysaccharide, and its compositio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L29/231A23L33/105A61K31/732A61P39/06A61P3/10A61K31/353
CPCA23L33/125A23L29/231A23L33/105A61K31/353A61K31/732A61P39/06A61P3/10A23V2002/00A23V2200/30A23V2250/21A23V2250/5072A23V2200/302A23V2200/328A61K2300/00
Inventor 吴茜张芬冯年捷王静祎周梦舟谈江莹牛梦遥
Owner HUBEI UNIV OF TECH
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