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High-throughput screening device

A screening device, high-throughput technology, applied in measuring devices, material analysis through optical means, instruments, etc., can solve problems such as sample contamination, and achieve good economic and social benefits

Pending Publication Date: 2022-07-01
上海科哲生化科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned shortcomings of the prior art, the purpose of the present invention is to provide a high-throughput screening device, which is used to solve the problem that biological autography and high-throughput screening are independent of each other in the prior art, which may cause damage to the cultured samples. pollution problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: the output shaft of the first motor 201 is connected with a lead screw, and the first fixing block 204 is a lead screw that is threadedly matched with the lead screw, or a connection block with a screw hole matched with the lead screw; the sampler 202 is The syringe includes a plunger or push needle and a sleeve, one end of the plunger or push needle is fixed on the first fixing block 204, and the plunger or push needle is driven by the first fixing block 204 and cooperates with the sleeve to complete sampling.

[0065] The above-mentioned embodiment also includes a necessary guide structure, which is parallel to the axial direction of the screw rod or the plunger, and slidingly cooperates with the first fixing block 204, and is used for the first fixing block 204 to be clamped and guided, so that the first fixed block The block 204 moves telescopically along a preset direction.

[0066] In this way, the processor sends a control signal to the first motor,...

Embodiment 2

[0067] Embodiment 2: The first motor 201 and the first fixing block 204 are replaced by hydraulic or pneumatic telescopic elements, and the plunger is telescopically moved under the driving of the hydraulic or pneumatic telescopic elements.

[0068] In addition, the processor 6 can also control the speed and amount of sample addition through the electric valve.

[0069] see figure 1 , the motion platform system 3 is arranged on one side of the sample adding system 2 to adjust the position of the sample to be added.

[0070] see image 3 , the motion platform system 3 includes: a second motor 301 , a second fixed block 302 , a second fixed plate 303 , a third motor 304 , a third fixed block 305 and a motion carrier platform 306 .

[0071] The output shaft of the second motor 301 is drivingly connected with the second fixing block 302 , the second fixing block 302 is fixedly connected with the second fixing plate 303 , and the second motor 301 is connected with the second fixi...

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Abstract

The invention provides a high-throughput screening device. The high-throughput screening device comprises a box body, and a sample adding system, a motion platform system, a light filtering system, an imaging and recognition system and a processor which are arranged in the box body, the sample adding system is used for automatically adding samples to the screening device; the motion platform system is used for adjusting the position of a sample to be added; the light filtering system is used for filtering the light source output by the imaging and recognition system; and the imaging and recognition system is used for providing a light source for the added sample and carrying out image acquisition and analysis on the added sample. A biological self-developing technology and high-throughput screening are combined, and an automatic sample adding device is additionally arranged, so that natural station service activity screening can be carried out through biological self-developing, the device can be applied to analysis and testing of biological samples, and the device has high-throughput analysis capacity and is suitable for separation and screening of active ingredients of natural products and food safety monitoring; and the method can also be used for chemiluminescence imaging test of biological pharmacy, and has good economic benefits and social benefits.

Description

technical field [0001] The invention relates to the technical field of drug screening, in particular to a high-throughput screening device. Background technique [0002] In the prior art, for the separation and screening of the active ingredients of traditional Chinese medicine and natural products and the drug metabolism analysis of the traditional Chinese medicine ingredients, most of them adopt the biological auto-imaging technology to culture the samples, and then put the cultured samples into high-throughput screening. in the device. [0003] Using this solution not only may contaminate the cultured samples, but also increases the user's operation steps. [0004] Therefore, how to design a high-throughput screening device that can combine autograph technology with high-throughput screening and can automatically add samples has become an urgent problem to be solved. SUMMARY OF THE INVENTION [0005] In view of the above-mentioned shortcomings of the prior art, the pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84G01N21/01G01N35/10
CPCG01N21/84G01N21/01G01N35/10
Inventor 张建明
Owner 上海科哲生化科技有限公司
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