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Sugar chain marker for predicting postoperative recurrence of thyroid cancer and application thereof

A thyroid cancer and marker technology, applied in the field of medical detection, can solve the problem of lack of evaluation of protein glycosylated thyroid cancer to predict recurrence of thyroid cancer and other problems

Active Publication Date: 2022-06-24
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of research evaluating whether protein glycosylation in thyroid cancer can be used to predict recurrence after thyroid cancer surgery

Method used

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  • Sugar chain marker for predicting postoperative recurrence of thyroid cancer and application thereof
  • Sugar chain marker for predicting postoperative recurrence of thyroid cancer and application thereof
  • Sugar chain marker for predicting postoperative recurrence of thyroid cancer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1 Differentially expressed N-glycans between PTC and healthy people (HC)

[0082] To evaluate the differential expression of serum N-glycans between PTC and healthy people (HC), 96 directly detected glycan structural traits and 91 derived glycan structural traits were compared. A series of differentially expressed glycan traits were found in PTC, postoperative follow-up patients (PS) and HC. In order to further explore whether the differentially expressed N-glycan traits between PTC and HC are responsive to the initial surgical resection treatment, the present invention compared the PTC group and the PS group according to the above differentially expressed glycan traits.

[0083] 16 directly detected glycan traits and 7 derived glycan traits were significantly different between PTC and PS. Among the directly detected sugar chain traits, H4N3F1L1 and H4N6F1E1 were lower in PS patients than in PTC patients, and showed a trend to normal levels (HC group) after tre...

Embodiment 2

[0084] Example 2 Diagnostic efficacy analysis of H4N3F1L1 and H4N6F1E1 for diagnosing PTC

[0085] In order to evaluate whether H4N3F1L1 and H4N6F1E1 can be used to diagnose PTC, the present invention carried out ROC curve analysis, such as figure 2 As shown, H4N3F1L1 (AUC value 0.718, sensitivity 71.3%, specificity 65.0%), H4N6F1E1 (AUC value 0.686, sensitivity 72.5%, specificity 66.2%) have potential as diagnostic markers for PTC.

Embodiment 3

[0086] Example 3 Application of H4N3F1L1 and H4N6F1E1 in predicting the recurrence of PTC

[0087] In order to investigate whether sugar chains that respond to surgical treatment have the potential to predict PTC recurrence, the present invention screened these traits by comparing postoperative recurrence patient population (PR) group and PS group. The present invention found that two directly detected sugar chain traits (H4N3F1L1 and H4N6F1E1) have potential as markers for monitoring and predicting the recurrence of PTC patients (such as image 3 shown). Compared with HC, these two glycan traits were up-regulated in PTC, and tended to be closer to normal levels after primary thyroidectomy. At the time of relapse, the level of 2 sugar chains increased again to approach the level of the PTC group (eg image 3 shown). These results suggest that two directly detected glycans, H4N3F1L1 and H4N6F1E1, may serve as new serum biomarkers for monitoring and predicting the recurrence ...

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Abstract

The invention discloses a sugar chain marker for predicting postoperative recurrence of thyroid cancer and application of the sugar chain marker, and particularly, the sugar chain marker comprises H4N3F1L1 and / or H4N6F1E1. The expression quantities of the markers have significant differences in healthy human bodies, thyroid cancer, thyroid cancer postoperative follow-up visit periods and thyroid cancer postoperative recurrence patients, so that the markers can be used for distinguishing the thyroid cancer patients from healthy people, and can also be used for distinguishing non-recurrence people and postoperative recurrence people after the thyroid cancer operation; the potential of predicting the postoperative recurrence of the thyroid cancer is realized.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and particularly relates to a sugar chain marker for predicting postoperative recurrence of thyroid cancer and its application. Background technique [0002] Thyroid cancer is the most common endocrine system malignancy. In recent years, the incidence has shown a significant upward trend. In my country, the number of new cases of thyroid cancer exceeds 190,000 each year, which seriously threatens the health of our population. Thyroid cancer is mainly divided into four pathological types. More than 90% are papillary thyroid carcinoma (Papillary Thyroid Carcinoma, PTC), and PTC has a good overall prognosis. Treatment strategies for PTC include surgical resection, postoperative radioactive iodine therapy, and thyrotropin suppression therapy. The 5-year overall survival rate is approximately 98.2%. Although PTC is an indolent tumor, metastases to regional cervical lymph nodes are often ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68G01N24/08G01N27/626G01N30/02G01N30/72
CPCG01N33/57407G01N33/57488G01N33/68G01N33/6851G01N27/628G01N30/7233G01N24/08G01N30/02
Inventor 刘子文曹桢张泽建徐协群
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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