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Endothelial and smooth muscle-like tissues produced from urine cells and related uses thereof

A urine cell, smoothing technology, applied in the field of cell pooling, can solve problems such as tumorigenic potential or low cell production efficiency

Pending Publication Date: 2022-05-17
EMORY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) stand out as promising alternatives; however, issues such as tumorigenic potential or inefficient cell production limit their clinical applications

Method used

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  • Endothelial and smooth muscle-like tissues produced from urine cells and related uses thereof
  • Endothelial and smooth muscle-like tissues produced from urine cells and related uses thereof
  • Endothelial and smooth muscle-like tissues produced from urine cells and related uses thereof

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Embodiment Construction

[0035] Before the present invention is described in greater detail, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.

[0036] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, the preferred methods and materials are now described.

[0037] All publications and patents cited in this specification are herein incorporated by reference as if each individual publication or patent we...

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Abstract

The present invention relates to endothelial and smooth muscle-like vascular tissues produced from urine cells. In certain embodiments, the present invention relates to methods of producing endothelium and smooth muscle-like vascular tissue by exposing urine-derived cells containing ETV2 to a first growth medium under conditions such that the cells are modified to form a cell pool with increased expression level of endothelial surface markers, and then separating the cells from the first growth medium. The cell pool is exposed to a second growth medium under conditions such that cells, which have increased smooth muscle surface marker expression levels in addition to endothelial cell surface markers, are modified to form a cell-containing tissue. In certain embodiments, the invention relates to the treatment of vascular, cardiac and wound healing related symptoms using the cells and tissues reported herein.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application Serial No. 62 / 903,154, filed September 20, 2019. The entire content of this application is incorporated herein by reference for all purposes. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with government support under DK108245, HL127759, and HL129511 awarded by the National Institutes of Health. The government has certain rights in this invention. [0005] Incorporation of references for materials submitted as text files via the Office Electronic Filing System (EFS-WEB) [0006] The Sequence Listing related to this application is provided in text format in lieu of a paper copy and is incorporated by reference into this specification. The text file containing the sequence listing is named 19161PCT_ST25.txt. The text file is 11KB, created on July 9, 2020, and submitted electronically via EFS-Web. Background te...

Claims

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Application Information

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IPC IPC(8): C12N5/10A61L27/36A61L27/38A61K35/22A61K35/44A61P17/00A61P9/00A61P9/14A61P9/10
CPCA61K35/44C12N2710/10343C12N5/069C12N2506/25C12N2501/11C12N2501/81C12N2533/54C12N2510/00C12N2501/165C12N2501/91C12N2500/38C12N2501/39C12N2513/00C12N5/0691A61L27/3625C12N2500/32C12N2500/34C12N2500/46C12N2501/115
Inventor 尹永燮杨-道格·索恩李相浩
Owner EMORY UNIVERSITY
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