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Methods and products for treating gastrointestinal disorders

A technology of rectal eubacterium and bacteria, applied in the direction of medical raw materials derived from bacteria, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of failing to reduce the relative risk of CDI recurrence

Pending Publication Date: 2022-05-13
FINCH THERAPEUTICS HLDG LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug failed to reduce the relative risk of CDI recurrence compared with placebo for up to eight weeks after treatment

Method used

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  • Methods and products for treating gastrointestinal disorders
  • Methods and products for treating gastrointestinal disorders
  • Methods and products for treating gastrointestinal disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0825] Embodiment 1: A pharmaceutical composition comprising a mixture of at least two bacterial isolates, wherein at least one of said bacterial isolates comprises at least 95% of the 16S rRNA sequence of the bacterial isolates provided in Table 1 16S rRNA sequence of identity, and wherein said at least two bacterial isolates are isolated from stool samples of different donors.

Embodiment approach 2

[0826] Embodiment 2: The pharmaceutical composition of Embodiment 1, wherein at least two of said bacterial isolates comprise a 16S rRNA having at least 95% identity to the 16S rRNA sequence of the bacterial isolates provided in Table 1 sequence.

Embodiment approach 3

[0827] Embodiment 3: The pharmaceutical composition of Embodiment 1 or Embodiment 2, wherein at least three of said bacterial isolates comprise a 16S rRNA sequence at least 95% identical to the bacterial isolates provided in Table 1 Sexual 16SrRNA sequence.

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PUM

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Abstract

Described herein are compositions and methods for delivering microbial therapeutic agents useful for the treatment of conditions associated with dysbacteriosis of intestinal flora. In various aspects, the present invention provides compositions and methods useful for treating or preventing inflammatory bowel disease (IBD) in a subject in need thereof. For example, the present invention relates, in part, to a plurality of bacterial isolates wherein at least two of the plurality of bacterial isolates are isolated from faeces of different human donors.

Description

[0001] priority [0002] This application claims the benefit and priority of U.S. Provisional Application No. 62 / 876,350, filed July 19, 2019, and U.S. Provisional Application No. 63 / 001,888, filed March 30, 2020, the contents of each of which are incorporated by reference in their entirety way incorporated into this article. technical field [0003] The present invention relates, in part, to compositions and methods for delivering bacterial isolates and / or mixtures of bacterial isolates useful for the treatment of disorders associated with intestinal dysbiosis. [0004] Instructions for text files submitted electronically [0005] This application contains a Sequence Listing. The Sequence Listing is submitted electronically via EFS-Web as an ASCII text file entitled "FIN-019PC_ST25". The size of the sequence listing is 65,811 bytes and was written on July 16, 2020. This Sequence Listing is incorporated herein by reference in its entirety. Background technique [0006] ...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P37/00A61P1/00
CPCA61K35/74A61P1/00C12N1/20A61K35/741A61P29/00A61P1/04
Inventor M·史密斯A-T·E·微欧R·萨多夫斯基J·亨斯克Y·杰拉尔丁S·提姆布莱克科斯马斯·贾洛乌拉基斯E·泰勒
Owner FINCH THERAPEUTICS HLDG LLC
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