Application of detection reagent of nasopharynx cancer related urine marker combination

A detection reagent and technology for nasopharyngeal carcinoma, applied in the field of medical testing, can solve the problems of low sensitivity and specificity of Epstein-Barr virus detection

Pending Publication Date: 2022-05-13
江西省肿瘤医院江西省第二人民医院江西省癌症中心
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Problems solved by technology

However, the sensitivity and specificity of EBV detection are not high

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  • Application of detection reagent of nasopharynx cancer related urine marker combination
  • Application of detection reagent of nasopharynx cancer related urine marker combination
  • Application of detection reagent of nasopharynx cancer related urine marker combination

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[0018] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments, but should not be construed as a limitation of the present invention. Unless otherwise specified, the technical means used in the following examples are conventional means well known to those skilled in the art, and the materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0019] Based on the metabolomics technology of ultra-high performance liquid chromatography-tandem time-of-flight mass spectrometry (UHPLC-Q-TOF MS), we studied the serum and urine samples of 27 patients with nasopharyngeal carcinoma and 27 normal healthy people (Table 1). Metabolic profile features in fluid samples. Through database matching, data standardization, metrology and statistical analysis, it was found that compared with normal healthy people, 181 metabolites in serum of nasopharyngeal carci...

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Abstract

The invention belongs to the technical field of medical examination, and particularly relates to application of a detection reagent of a urine marker combination related to nasopharyngeal carcinoma, the application is particularly application in preparation of products for diagnosis and/prognosis of nasopharyngeal carcinoma, the marker combination is Methyl (1-(cyclocylmethl)-1h-indide-3-carbonyl)-l-valine, Stacdrine, Decanoyl-1-carnitine and Octanoylcarnitine, and the CAS number of the marker combination is 1971007-94-9, 471-87-4, 1492-27-9 and 25243-95-2 in sequence. By quantitatively detecting the marker in urine of a subject, the incidence of nasopharyngeal carcinoma can be well predicted, and a specific, rapid and noninvasive detection means is provided for early diagnosis of nasopharyngeal carcinoma.

Description

technical field [0001] The invention belongs to the technical field of medical testing, and in particular relates to the application of a detection reagent for a nasopharyngeal carcinoma-related urine marker combination. Background technique [0002] The main pathogenic factors of nasopharyngeal carcinoma include genetic susceptibility, dietary factors and Epstein-Barrvirus (EBV) infection. The research on its pathogenesis includes gene mutation, metabolomics, proteomics, genomics and other aspects. Nevertheless, it is still difficult to fully understand the occurrence and development of nasopharyngeal carcinoma, which brings difficulties to its treatment. [0003] Generally speaking, the diagnosis of nasopharyngeal carcinoma is still based on nasopharyngoscopy, but it is expensive and harmful to the human body; further diagnosis of nasopharyngeal carcinoma still needs to rely on tissue pathological diagnosis, but tissue biopsy is invasive. The patient is more painful. At ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72
Inventor 饶军李金高廖朝晖卢天柱钟方炎
Owner 江西省肿瘤医院江西省第二人民医院江西省癌症中心
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