Traditional Chinese medicine compound radix clematidis and radix angelicae sinensis granules for treating asthenospermia by applying brain-heart-kidney-spermatoventricular axis theory and preparation method

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses traditional Chinese medicine compound radix clematidis and radix angelicae sinensis granules for treating asthenospermia by applying a brain-heart-kidney-spermatoventricular axis theory and a preparation method of the traditional Chinese medicine compound radix clematidis and radix angelicae sinensis granules. The traditional Chinese medicine compound radix clematidis and radix angelicae sinensis granules for treating asthenospermia by applying a brain-heart-kidney-spermatoventricular axis theory are prepared by the following steps: weighing 6-10g of radix clematidis, 6-12g of radix angelicae sinensis, 9-15g of radix rehmanniae preparata, 6-12g of semen cuscutae, 9-15g of semen plantaginis, 3-6g of rhodiola rosea and 9-27g of radix acanthopanacis senticosi according to a proportion, and preparing a radix angelicae sinensis granule preparation. Effectiveness and safety verification of the traditional Chinese medicine compound granules for treating asthenospermia is carried out. The traditional Chinese medicine compound granules can significantly enhance sperm activity of weak sperm patients and improve kidney deficiency and blood stasis symptoms of the patients, and have no adverse reaction. The research proves from the animal level that the traditional Chinese medicine compound granules can relieve epididymal injury, increase epididymal SOD and GSH-Px activity, reduce MDA content, reduce epididymal oxidative injury of an asthenospermia model rat and maintain a normal sperm maturation environment.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine compound Linggui granule for treating asthenozoospermia and a preparation method thereof. Background technique [0002] Male infertility is a global health problem. According to the 2020 European Association of Urology Guidelines for Male Infertility, about 15% of couples of childbearing age worldwide seek medical treatment because they cannot conceive naturally within one year. About 70 million families around the world are suffering from infertility. Male factors account for 50% of the causes of infertility. However, there is still a gap in male reproductive health care compared with females. Clinically, asthenospermia is the cause of One of the main causes of male infertility. Evidence of reduced semen quality in young, healthy men has been accumulating in recent years. Asthenozoospermia occurs in 81% of all ab...

AI Technical Summary

Problems solved by technology

[0013] However, there are still some problems in the research of TCM treatment of asthenozoospermia, such as non-standard syndromes, clinical research design methods need to be improved, and the specific mechanism of action has not been studied in depth, etc.

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