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Application of LINC01996 in diagnosis of allergic airway inflammation

A technology for airway inflammation and allergic rhinitis, applied in the field of biomedicine, can solve the problems of few biomarker research reports

Active Publication Date: 2021-12-21
CHANGZHOU NO 2 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on biomarkers that can be used to diagnose allergic rhinitis-asthma syndrome

Method used

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  • Application of LINC01996 in diagnosis of allergic airway inflammation
  • Application of LINC01996 in diagnosis of allergic airway inflammation
  • Application of LINC01996 in diagnosis of allergic airway inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Real Time PCR Detection of Changes in the Expression of Target Genes in Blood Samples of Patients with Allergic Rhinitis-Asthma Syndrome

[0058] 1. Purpose of the experiment

[0059] The SYBR GreenⅠReal Time PCR method was used to detect the changes of lncRNA transcription level of the target gene in the blood samples of patients with allergic rhinitis-asthma syndrome.

[0060] 2. Experimental materials

[0061] 1. Sample Checklist

[0062] In this study, 20 patients with allergic rhinitis-asthma syndrome and 20 normal subjects were recruited. The clinical information is shown in Table 1. Blood samples were collected for analysis and research.

[0063] Table 1 Basic clinical information of the people involved in this study

[0064]

[0065] 2. Experimental main reagents

[0066] Table 2 List of Reagents Used

[0067]

[0068] 3. The main instruments of the experiment

[0069] Table 3 list of equipment used

[0070]

[0071]

[0072] 3. Expe...

Embodiment 2

[0127] Embodiment 2 The diagnostic efficacy verification of LINC01996

[0128] Receiver operating curve (ROC) was drawn by SPSS software, AUC value, sensitivity and specificity were analyzed, and the diagnostic efficacy of the indicators alone was judged.

[0129] As shown in Table 9, Figure 5 As shown, LINC01996 has high diagnostic efficiency (AUC value 0.858, sensitivity value 0.750, specificity value 0.850), suggesting that LINC01996 can be used to diagnose allergic rhinitis-asthma syndrome.

[0130] Table 9 The area under the ROC curve

[0131]

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PUM

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Abstract

The invention discloses application of LINC01996 in the diagnosis of allergic airway inflammation. By detecting the expression level of the LINC01996, the allergic airway inflammation can be quickly and accurately diagnosed. The LINC01996 as the marker can improve the sensitivity and specificity of the diagnosis of allergic airway inflammation, and has important clinical significance and application prospects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of LINC01996 in diagnosing allergic airway inflammation. Background technique [0002] Allergic rhinitis-asthma syndrome (Combined Allergic Rhinitis and Asthma Syndrome, CARAS) is a new medical diagnosis concept proposed by the World Allergy Organization (WAO), referring to simultaneous, clinical or subclinical upper respiratory tract Allergy (allergic rhinitis, allergic rhinitis, AR) and lower respiratory tract allergy (bronchial asthma, bronchial asthma, BA) caused by chronic allergic inflammation and hyperresponsive symptoms. AR is an allergic disease that occurs in the nasal mucosa, manifested as increased nasal secretions caused by catarrhal inflammation, swelling of the nasal mucosa, watery runny nose, nasal congestion, and nasal itching and sneezing caused by hyperresponsiveness. BA manifests as airway desquamative inflammation, hyperresponsiveness (...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/6851G16B25/20G16B40/00G16H50/20G16H50/70
CPCC12Q1/6883C12Q1/6851G16B25/20G16B40/00G16H50/20G16H50/70C12Q2600/158C12Q2600/178C12Q2563/107C12Q2531/113
Inventor 毛正道刘志光张倩
Owner CHANGZHOU NO 2 PEOPLES HOSPITAL
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