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Medical application of NRK in treatment and prognosis of lung cancer

A technology for lung cancer and prognosis, applied in the field of biomedicine, can solve the problems that the mechanism of NRK expression kinase activity and regulation signal cascade has not been elucidated, and the medical use of NRK in lung cancer treatment and prognosis diagnosis has not been found, so as to achieve good diagnostic and prognostic indicators Effect

Pending Publication Date: 2021-11-26
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology

However, the expression of NRK in other tissues or cells, its substrates, and the mechanisms that regulate its kinase activity and regulate signaling cascades have not been elucidated
At present, the relevant medical application of NRK in the treatment and prognosis of lung cancer has not been found

Method used

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  • Medical application of NRK in treatment and prognosis of lung cancer
  • Medical application of NRK in treatment and prognosis of lung cancer
  • Medical application of NRK in treatment and prognosis of lung cancer

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Embodiment Construction

[0051] In order to understand the above-mentioned purpose, features and advantages of the present invention more clearly, the technical solutions of the present invention will be described in further non-limiting detail below in conjunction with the accompanying drawings and specific embodiments.

[0052] 1. Materials and methods

[0053] Lung adenocarcinoma tissues and their corresponding non-malignant lung tissues (at least 5 cm away from the tumor) were collected prospectively from patients with primary lung adenocarcinoma diagnosed in the Cancer Hospital Affiliated to Guangxi Medical University. Selection criteria included: 1) pathological diagnosis of LUAD; 2) patients did not receive chemotherapy or radiotherapy before surgery; 3) patients had no history of other types of tumors; 4) patients had complete medical records. Patients who lacked AJCC staging information, lacked histological information, and died within 30 days after surgery or from other causes of disease wer...

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Abstract

The invention discloses medical application of NRK in treatment and prognosis of lung cancer. The invention specifically relates to application of the NRK in preparation of products for diagnosing prognosis of the lung cancer and application of the NRK in preparation of drugs for treating the lung cancer. The invention also discloses application of a NRK neutralizing antibody in preparation of products for diagnosing lung cancer and application of the NRK neutralizing antibody in preparation of the drugs for treating the lung cancer. CAFs and NFs from LUAD I, II and III stages are analyzed by using RNA-seq and a comprehensive bioinformatics method, the specific expression of the NRK in lung cancer tumor-related fibroblasts is found, the NRK can be used as a clinical diagnosis biomarker of the lung cancer, and a better diagnosis and prognosis index can be provided; the NRK in the LUAD-related CAFs is obviously increased, and the NRK can be used as a target spot of LUAD combined treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the medical application of NRK in the treatment and prognosis diagnosis of lung cancer. Background technique [0002] The morbidity and mortality of lung cancer rank first in the world. Lung cancer is divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), of which NSCLC accounts for 85% of all lung cancers. NSCLC is mainly divided into adenocarcinoma (LUAD), squamous cell carcinoma (LUSC) and large cell carcinoma. LUAD is the main subtype of NSCLC, accounting for about 50% of NSCLC. Although the rapid development of clinical treatment methods such as surgery, chemotherapy, targeted therapy and immunotherapy have significantly improved the prognosis of lung cancer patients including LUAD, the prognosis of these patients is still poor due to drug resistance or poor response to drug therapy , the 5-year average survival rate is only 15%. In additio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/573A61K39/395A61P35/00
CPCC12Q1/6886G01N33/57423G01N33/57496G01N33/573A61K39/3955A61P35/00C12Q2600/118C12Q2600/158G01N2333/91215
Inventor 阳洁韦彤彤宋锦静莫孝成黎骊莫小香沈小菊陈罡黄志广
Owner GUANGXI MEDICAL UNIVERSITY
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