Application of curcumin metabolites in the preparation of drugs for the treatment of myocardial ischemia-related injuries

A technique for myocardial ischemia and metabolites, which is used in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc. to reduce pathological manifestations, reduce tissue fibrosis-like changes, and reduce ventricular dilatation.

Active Publication Date: 2022-06-21
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

However, there is no report on whether metabolites also have the effect of interfering with MIRI

Method used

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  • Application of curcumin metabolites in the preparation of drugs for the treatment of myocardial ischemia-related injuries
  • Application of curcumin metabolites in the preparation of drugs for the treatment of myocardial ischemia-related injuries
  • Application of curcumin metabolites in the preparation of drugs for the treatment of myocardial ischemia-related injuries

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Embodiment Construction

[0023] In order to make the technical problems, technical solutions and advantages to be solved by the present invention more clear, the following will be described in detail with reference to specific embodiments.

[0024] The present invention first compares the effect of curcumin and its metabolites on the RAW264.7 macrophage model induced by bacterial lipopolysaccharide (LPS), selects metabolites with higher activity to study whether it has a therapeutic effect on MIRI, and further utilizes transcriptional The omics technology was used to explore the prognosis of MIRI and the influence of curcumin metabolites on the process of MIRI, and to provide a theoretical basis for curcumin metabolites to be used in the treatment of MIRI.

[0025] English abbreviations English full name Chinese full name α-HBDH Alpha-hydroxybutyrate dehydrogenase alpha-hydroxybutyrate dehydrogenase AI Apoptotic Index Apoptosis Index ɑ-SMA alpha-smooth muscle acti...

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Abstract

The invention provides the application of curcumin metabolites in the preparation of medicines for treating myocardial ischemia-related injuries. Through the research on the intervention effect of the rat MIRI model, the present invention finds that both CUR and OHC can improve the damaged heart function and the performance of serum myocardial enzymes, reduce the degree of ventricle enlargement, reduce the apoptosis of myocardial cells and tissue fibrosis-like changes, and alleviate the effects of MIRI. Pathological manifestations, and the improvement effect of OHC is slightly better. Therefore, the present invention will help to understand the molecular mechanism of MIRI disease process, and provide valuable scientific basis for explaining the pharmacodynamic mechanism of CUR and its active metabolite OHC.

Description

technical field [0001] The invention relates to the application of curcumin metabolites in the preparation of medicaments for treating myocardial ischemia-related injury. Background technique [0002] The incidence of ischemic cardiomyopathy is increasing year by year, seriously endangering human health. In the clinical treatment guidelines, restoring blood perfusion in the ischemic area as soon as possible is the key to rescue, but perfusion also brings more serious damage, which will further aggravate ischemic damage in a short period of time, and then lead to ventricular remodeling, Symptoms such as arrhythmia, and eventually even heart failure. This phenomenon of restoring blood perfusion and further aggravating myocardial injury is called myocardial ischemia-reperfusion injury (Myocardial Ischemia Reperfusion Injury, MIRI). MIRI is a complex pathophysiological process involving multiple factors. It is very common in clinical practice, such as thrombolysis and stent im...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K31/09A61P9/10A61K36/9066A61K125/00
CPCA61K31/12A61K31/09A61P9/10A61K36/9066
Inventor 谢庆凤徐洋苏子仁陈金芬
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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