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Application of three metabolic markers independently or jointly in preparation of kit for diagnosing systemic lupus erythematosus

A technology of metabolic markers and lupus erythematosus, applied in the field of biochemistry, can solve the problems of diagnostic markers to be developed and achieve high diagnostic accuracy

Active Publication Date: 2021-07-16
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] More diagnostic markers to be developed

Method used

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  • Application of three metabolic markers independently or jointly in preparation of kit for diagnosing systemic lupus erythematosus
  • Application of three metabolic markers independently or jointly in preparation of kit for diagnosing systemic lupus erythematosus
  • Application of three metabolic markers independently or jointly in preparation of kit for diagnosing systemic lupus erythematosus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Diagnostic efficiency of metabolic markers for systemic lupus erythematosus

[0021] 1. Experimental samples and reagents

[0022] 130 healthy subjects and 130 patients with systemic lupus erythematosus were collected from Jiangsu Provincial Hospital of Traditional Chinese Medicine. Healthy subjects were normal people with healthy physical examination, and patients with systemic lupus erythematosus were included according to the systemic lupus erythematosus classification criteria of the American College of Rheumatology. The groups were matched for age, sex, and body mass index, and there were no significant differences. According to Table 1, subjects or patients in each group were randomly divided into training set samples and validation set samples.

[0023] Table 1 Number of training set samples and validation set samples

[0024] Healthy subjects (SS) Patients with systemic lupus erythematosus (HCS) Training set 85 85 validati...

Embodiment 2

[0064] Embodiment 2: Diagnostic kit

[0065] A kit for diagnosing systemic lupus erythematosus, comprising detection reagents for detecting one or any two or all three of arabitol, asparagine and stearic acid.

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Abstract

The invention discloses application of three metabolic markers independently or jointly in preparation of a kit for diagnosing systemic lupus erythematosus. The metabolic markers which are arabitol, asparagine and stearic acid provided by the invention can be used for diagnosing and distinguishing healthy people and systemic lupus erythematosus patients independently or by combining any two or three of the metabolic markers, and the diagnosis accuracy is high, so that the metabolic markers have the prospect of being developed and prepared into a kit for diagnosing systemic lupus erythematosus. In addition, the diagnostic index provided by the invention is serum metabolite, can be detected only by taking a small amount of blood, and is basically noninvasive.

Description

technical field [0001] The invention belongs to the field of biochemistry and relates to the application of metabolic markers in disease diagnosis, in particular to the application of three metabolic markers alone or in combination in the preparation of a kit for diagnosing systemic lupus erythematosus. Background technique [0002] Systemic lupus erythematosus (SLE) is a systemic autoimmune disease related to genetics, sex hormones, infection and other factors. Its main clinical features are the involvement of multiple systems and organs, repeated relapses and remissions, and the presence of a large number of autoantibodies in the body. Patients may present with symptoms such as annular erythema, mental changes, and anemia. [0003] In actual clinical practice, the few markers widely used for SLE diagnosis or disease activity are still limited to antinuclear antibodies, complement, and several autoantibodies. [0004] More diagnostic markers are yet to be developed. In re...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88
Inventor 刘史佳郭峰王颖卓
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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